Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleSeparate and combined effects of the cannabinoid agonists nabilone and Δ(9)-THC in humans discriminating Δ(9)-THC.
Author(s)Lile JA, Kelly TH, Hays LR.
Journal, Volume, IssueDrug Alcohol Depend. 2011 Jul 1;116(1-3):86-92.
Major outcome(s)THC caused similar effects as nabilone
IndicationAbstract
MedicationDelta-9-THC;Nabilone

BACKGROUND: Agonist replacement treatment is a promising strategy to manage cannabis-use disorders. The aim of this study was to assess the combined effects of the synthetic cannabinoid agonist nabilone and Δ(9)-tetrahydrocannabinol (Δ(9)-THC) using drug-discrimination procedures, which are sensitive to drug interactions. Testing the concurrent administration of nabilone and Δ(9)-THC was also conducted to provide initial safety and tolerability data, which is important because cannabis users will likely lapse during treatment. METHODS: Six cannabis users learned to discriminate 30mg oral Δ(9)-THC from placebo and then received nabilone (0, 1 and 3mg) and Δ(9)-THC (0, 5, 15 and 30mg), alone and in combination. Subjects completed the multiple-choice procedure to assess drug reinforcement, and self-report, task performance and physiological measures were collected. RESULTS: Δ(9)-THC and nabilone alone shared discriminative-stimulus effects with the training dose of Δ(9)-THC, increased crossover point on the multiple-choice procedure, produced overlapping subject ratings and decreased skin temperature. Nabilone alone also elevated heart rate. In combination, nabilone shifted the discriminative-stimulus effects of Δ(9)-THC leftward/upward and enhanced Δ(9)-THC effects on the other outcome measures. CONCLUSIONS: These results replicate a previous study demonstrating that nabilone shares agonist effects with the active constituent of cannabis in cannabis users, and contribute further by indicating that nabilone would likely be safe and well tolerated when combined with cannabis. These data support the conduct of future studies to determine if nabilone treatment would produce cross-tolerance to the abuse-related effects of cannabis and reduce cannabis use.

Route(s)Oral
Dose(s)
Duration (days)
Participants6 healthy cannabis users
DesignControlled study
Type of publicationMedical journal
Address of author(s)Department of Behavioral Science, University of Kentucky College of Medicine, College of Medicine Office Building, Lexington, KY 40536-0086, United States.
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