Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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Title[Cannabinoids in children] [Article in German] Cannabinoide bei Kindern.
Author(s)Gottschling S.
Journal, Volume, IssueAngewandte Schmerztherapie und Palliativmedizin 2011;(1):55-57.
Major outcome(s)Reduced pain, spasticity and improved appetite and nausea
IndicationAppetite loss/weight loss;Cancer;Nausea/vomiting;Pain;SpasticityAbstract
MedicationDelta-9-THC

From the IACM Bulletin:

According to case reports of the Centre for Palliative Medicine and Paediatric Pain Therapy of the University of the Saarland (Germany) THC (dronabinol) is an effective and well-tolerated medicinal drug in the treatment of different severe illnesses in children. A scientist of a university reported of experiences from the treatment of 13 children with severe disabilities and spasticity aged 7 months to 17 years as well as of about 50 cancer patients aged three months and older.

All children received a slowly increased dose. Mean dronabinol dose was 0.2 mg/kg bodyweight in children with spasticity and pain after finishing dose finding. In all children a reduction in pain, which was considerable in some of them, was observed within 48 hours after start of treatment. Efficacy with regard to spasticity set in within one to two weeks. In some patients opioid treatment could be reduced. Most cancer patients profited from an increase in appetite and weight, reduction of nausea and vomiting, as well as improved sleep and reduced anxiety. Even with long-term treatment no relevant side-effects were noted.

Route(s)Oral
Dose(s)0.2 mg/kg
Duration (days)
Participants13 children with severe spasticity and 50 children with canc
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)Universitätsklinikum des Saarlandes, 66421 Homburg, Germany, E-Mail: sven.gottschling@uks.eu
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