Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleIncreased Blood Pressure Following Abrupt Cessation of Daily Cannabis Use.
Author(s)Vandrey R, Umbricht A, Strain EC.
Journal, Volume, IssueJ Addict Med. 2011 Mar;5(1):16-20.
Major outcome(s)In 6 of 13 subjects blood pressure increased significantly after cessation of cannabis use.
IndicationAbstract
MedicationCannabis;Nabilone

OBJECTIVE: Cannabis is the most widely used illicit drug. Acute cannabis administration increases blood pressure and heart rate and tolerance develops to these effects with heavy use. A valid and reliable withdrawal syndrome occurs in most daily users, but few studies have assessed the cardiovascular effects of withdrawal. The objective of this report is to describe unexpected changes in cardiovascular function during brief periods of supervised cannabis use and abstinence in daily cannabis users. METHODS: A within-subjects ABAC crossover study in which inpatient volunteers smoked cannabis ad-libitum (A), and abstained from cannabis (B/C). Vital signs were obtained three times daily during eleven inpatient days for thirteen daily cannabis users (11 Male, 8 African American). RESULTS: Blood pressure increased significantly during periods of cannabis abstinence compared with periods of cannabis use. The magnitude of increase was substantial in a subset (N=6) of participants, with mean increases of up to 22.8mmHg systolic and 12.3mmHg diastolic blood pressure observed. Heart rate also increased during abstinence when measures collected during periods of acute intoxication were excluded, but the magnitude of effect was not clinically significant. CONCLUSIONS: Abrupt cessation of heavy cannabis use may cause clinically significant increases in blood pressure in a subset of users. Blood pressure should be monitored among those attempting to reduce or quit frequent cannabis use, particularly those with preexisting hypertension. The time course of this effect is currently unknown and requires further study.

Route(s)Inhalation
Dose(s)
Duration (days)
Participants13 regular cannabis users
DesignSurvey
Type of publicationMedical journal
Address of author(s)Johns Hopkins University School of Medicine.
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