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|Title||Increased Blood Pressure Following Abrupt Cessation of Daily Cannabis Use.|
|Author(s)||Vandrey R, Umbricht A, Strain EC.|
|Journal, Volume, Issue||J Addict Med. 2011 Mar;5(1):16-20.|
|Major outcome(s)||In 6 of 13 subjects blood pressure increased significantly after cessation of cannabis use.|
OBJECTIVE: Cannabis is the most widely used illicit drug. Acute cannabis administration increases blood pressure and heart rate and tolerance develops to these effects with heavy use. A valid and reliable withdrawal syndrome occurs in most daily users, but few studies have assessed the cardiovascular effects of withdrawal. The objective of this report is to describe unexpected changes in cardiovascular function during brief periods of supervised cannabis use and abstinence in daily cannabis users. METHODS: A within-subjects ABAC crossover study in which inpatient volunteers smoked cannabis ad-libitum (A), and abstained from cannabis (B/C). Vital signs were obtained three times daily during eleven inpatient days for thirteen daily cannabis users (11 Male, 8 African American). RESULTS: Blood pressure increased significantly during periods of cannabis abstinence compared with periods of cannabis use. The magnitude of increase was substantial in a subset (N=6) of participants, with mean increases of up to 22.8mmHg systolic and 12.3mmHg diastolic blood pressure observed. Heart rate also increased during abstinence when measures collected during periods of acute intoxication were excluded, but the magnitude of effect was not clinically significant. CONCLUSIONS: Abrupt cessation of heavy cannabis use may cause clinically significant increases in blood pressure in a subset of users. Blood pressure should be monitored among those attempting to reduce or quit frequent cannabis use, particularly those with preexisting hypertension. The time course of this effect is currently unknown and requires further study.
|Participants||13 regular cannabis users|
|Type of publication||Medical journal|
|Address of author(s)||Johns Hopkins University School of Medicine.|