Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleOpen-label, add-on study of tetrahydrocannabinol for chronic nonmalignant pain.
Author(s)Haroutiunian S, Rosen G, Shouval R, Davidson E.
Journal, Volume, IssueJ Pain Palliat Care Pharmacother. 2008;22(3):213-7.
Major outcome(s)5 patients reported adequate response to the treatment.
IndicationPainAbstract
MedicationDelta-9-THC

Cannabinoids have been used for pain relief for centuries and recent studies have investigated their analgesic and anti-inflammatory mechanisms, as well as clinical efficacy, in treating chronic pain. We report an open-label study addressed to evaluate the effect and adverse events of orally administered Delta-9-tetrahydrocannabinol (Delta-9-THC) in 13 patients with chronic nonmalignant pain (CNMP) unresponsive to conventional pharmacotherapy. The effect of the treatment was assessed on an eight-item HRQoL questionnaire. Five out of 13 patients reported adequate response to the treatment while eight patients reported inadequate or no response. Seven patients did not experience any adverse events (AEs), six patients reported AEs, two of which discontinued the treatment. We conclude that oral THC may be a valuable therapeutic option for selected patients with CNMP that are unresponsive to previous treatments, though further research is warranted to characterize those patients.

Route(s)Oral
Dose(s)
Duration (days)
Participants13 pain patients
DesignOpen study
Type of publicationMedical journal
Address of author(s)Department of Anesthesiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
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