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|Title||Müller-Vahl KR, Schneider U, Emrich HM.|
|Author(s)||Combined treatment of Tourette syndrome with delta-9-THC and dopamine receptor agonists.|
|Journal, Volume, Issue||J Cannabis Ther 2002;2(3-4):145-54.|
|Major outcome(s)||THC may be combined with neuroleptics|
Animal studies suggest that cannabinoid receptor agonists might enhance the effect of dopamine receptor antagonists (neuroleptics, NL) in hyperkinetic movement disorders. In Tourette syndrome, NL are the most effective drugs for the treatment of tics. Recent clinical trials demonstrated that delta-9-tetrahydrocannabinol (delta-9-THC) also produces a tic-suppressing effect. In this single case study in a 24 years old female suffering from TS with extreme tics, it is suggested for the first time that delta-9-THC may be useful in augmenting the pharmacological response to atypical NL such as amisulpride and risperidone in TS patients. No serious adverse reactions occurred. Controlled studies are necessary to confirm this initial report.
|Participants||1 patient with Tourette's syndrome|
|Design||Uncontrolled case report|
|Type of publication||Medical journal|
|Address of author(s)||Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Germany.|