Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleDelta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo
Author(s)Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA
Journal, Volume, IssueVeterinary and Human Toxicology 1979;21:338-340
Major outcome(s)dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently)
IndicationNausea/vomiting;Cancer;Cancer chemotherapyAbstract
MedicationDelta-9-THC

Summary
A double-blind cross-over trial with delta-9-tetrahydrocannabinol (THC) and placebo was employed to test the antiemetic effect on nausea and vomiting after MOPP-therapy. Although THC had remarkable antiemetic effects, there side effects were severe. Most patients preferred the nausea and the vomiting after MOPP-therapy to the use of THC. A relation between the antiemetic action or the side-effects and the blood-level of THC could not be demonstrated.

Route(s)Oral
Dose(s)10 mg/m2 every 4 h, 3 doses a day
Duration (days)on day 1 and day 8 of chemotherapy
Participantspatients receiving MOPP chemotherapy
DesignControlled study
Type of publication
Address of author(s)
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