On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
patients.
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| Title | Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo |
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| Author(s) | Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA |
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| Journal, Volume, Issue | Veterinary and Human Toxicology 1979;21:338-340 |
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| Major outcome(s) | dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently) |
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| Indication | Nausea/vomiting;Cancer;Cancer chemotherapy | Abstract |
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| Medication | Delta-9-THC | Summary
A double-blind cross-over trial with delta-9-tetrahydrocannabinol (THC) and placebo was employed to test the antiemetic effect on nausea and vomiting after MOPP-therapy. Although THC had remarkable antiemetic effects, there side effects were severe. Most patients preferred the nausea and the vomiting after MOPP-therapy to the use of THC. A relation between the antiemetic action or the side-effects and the blood-level of THC could not be demonstrated.
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| Route(s) | Oral |
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| Dose(s) | 10 mg/m2 every 4 h, 3 doses a day |
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| Duration (days) | on day 1 and day 8 of chemotherapy |
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| Participants | patients receiving MOPP chemotherapy |
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| Design | Controlled study |
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| Type of publication | |
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| Address of author(s) | |
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| Full text |
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