Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleCannabis improves night vision: A pilot study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif Mountains of Northern Morocco.
Author(s)Russo EB, Merzouki A, Molero Mesa J, Frey KA, Bach PJ.
Journal, Volume, IssueJ Ethnopharmacol 2004;93(1):99-104.
Major outcome(s)Oral THC and smoking of cannabis improved night vision
IndicationAbstract
MedicationCannabis;Delta-9-THC

Previous reports have documented an improvement in night vision among Jamaican fishermen after ingestion of a crude tincture of herbal cannabis, while two members of this group noted that Moroccan fishermen and mountain dwellers observe an analogous improvement after smoking kif, sifted Cannabis sativa mixed with tobacco (Nicotiana rustica). Field-testing of night vision has become possible with a portable device, the LKC Technologies Scotopic Sensitivity Tester-1 (SST-1). This study examines the results of double-blinded graduated THC administration 0-20 mg (as Marinol) versus placebo in one subject on measures of dark adaptometry and scotopic sensitivity. Analogous field studies were performed in Morocco with the SST-1 in three subjects before and after smoking kif. In both test situations, improvements in night vision measures were noted after THC or cannabis. It is believed that this effect is dose-dependent and cannabinoid-mediated at the retinal level. Further testing may assess possible clinical application of these results in retinitis pigmentosa or other conditions.

Route(s)Inhalation;Oral
Dose(s)
Duration (days)
Participants4 healthy subjects
DesignControlled study
Type of publicationMedical journal
Address of author(s)erusso@montanadsl.net
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