Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleThe effect of extreme marijuana use on the long-term course of bipolar I illness: a single case study.
Author(s)El-Mallakh RS, Brown C.
Journal, Volume, IssueJ Psychoactive Drugs 2007;39(2):201-2.
Major outcome(s)Cannabis decreased the number of depressed days and increased the number of hypomanic days.
IndicationBipolar disordersAbstract
MedicationCannabis

The effect of marijuana on bipolar disorder has never been systematically evaluated. Subjective reports by patients suggest an overall positive effect, but these may be unreliable. We herein report a case in which mood data was prospectively collected over two years of total substance abstinence and two years of extreme marijuana use. Marijuana use did not alter the total number of days of abnormal mood, however, marijuana was associated with an increase in the number of hypomanic days and a decrease in the number of depressed days. While not conclusive, the data suggest that marijuana may indeed have an effect on mood in bipolar patients that needs to be systematically examined.

Route(s)Inhalation
Dose(s)
Duration (days)1400
ParticipantsA patient with bipolar disorder
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA.
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