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|Title||An initial evaluation of Nabilone in the control of radiotherapy-induced nausea and vomiting.|
|Author(s)||Priestman TJ, Priestman SG.|
|Journal, Volume, Issue||Clin Radiol. 1984 Jul;35(4):265-6.|
|Major outcome(s)||Patients who did not respond to metaclopramide responded to nabilone.|
Nabilone is a cannabinoid anti-emetic which has been extensively evaluated in control of chemotherapy-induced vomiting. A pilot study was undertaken to assess the efficacy of Nabilone in controlling radiotherapy-induced vomiting resistant to a conventional anti-emetic (metoclopramide). Thirty patients receiving wide-field upper abdominal irradiation were prospectively monitored. Fourteen developed no significant nausea or vomiting and in 10 symptoms were controlled by metaclopramide. All six patients who failed to respond to this agent responded to Nabilone. Toxicity with both drugs was minimal. Although patient numbers were small, this initial assessment suggests that Nabilone may be a useful agent in the control of resistant radiation-induced sickness.
|Participants||30 patients undergoing radiotherapy|
|Type of publication||Medical journal|
|Address of author(s)|