Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleThe efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety.
Author(s)Fabre LF, McLendon D.
Journal, Volume, IssueJ Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):377S-382S.
Major outcome(s)Dramatic improvement in anxiety

The ANXIOLYTIC properties of nabilone, a synthetic cannabinoid resembling the natural cannabinoids, were studied in 25 outpatients suffering from anxiety. The drug was compared with a placebo in a double-blind manner over a 28-day treatment period. Patients were seen weekly by the physician and were rated by the Hamilton Rating Scale for Anxiety and the Patient's Global Evaluation as well as by patient-rated evaluations. The results of the study showed a dramatic improvement in anxiety in the nabilone group when compared with placebo (P less than 0.001). Side effects reported were dry mouth, dry eyes, and drowsiness. Patients did not report any of the subjective "altered state" experience of marihuana.

Duration (days)28
Participants25 patients with anxiety
DesignControlled study
Type of publicationMedical journal
Address of author(s)
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