Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleCannabis use in sickle cell disease: a questionnaire study.
Author(s)Howard J, Anie KA, Holdcroft A, Korn S, Davies SC.
Journal, Volume, IssueBr J Haematol 2005;131(1):123-8.
Major outcome(s)36% had used cannabis to treat symptoms
IndicationPain;Depression;AnxietyAbstract
MedicationCannabis

Cannabinoids are increasingly being considered for the management of various painful conditions, and could be considered as an option for treating acute pain in sickle cell disease (SCD). The objective of this study was to determine the extent of use of cannabis in the community for pain and other symptom relief, and its side effects during self-administration in patients with SCD. Patients attending Central Middlesex Hospital in London were invited to complete a structured self-administered anonymous questionnaire. Eighty-six young adults with HbSS, HbSC and HbSbetathalassaemia disease (median age 30 years) participated in the study. Results showed that 31 (36%) had used cannabis in the previous 12 months to relieve symptoms associated with SCD. The main route in all but two patients was by smoking. The main reasons for use were to reduce pain in 52%, and to induce relaxation or relieve anxiety and depression in 39%. Symptoms related to sedation and mood effects were reported in 77% of patients. The majority of patients (58%) expressed their willingness to participate in studies of cannabis as a medicine. We conclude that research in the use of cannabinoids for pain relief in SCD would be both important and acceptable to adult patients.

Route(s)Inhalation
Dose(s)
Duration (days)
Participants86 patients with sickle cell disease
DesignSurvey
Type of publicationMedical journal
Address of author(s)Department of Haematology, Central Middlesex Hospital, London, UK. jo.howard@nwlh.nhs.uk
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