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|Title||Vaporization as a smokeless cannabis delivery system: a pilot study.|
|Author(s)||Abrams DI, Vizoso HP, Shade SB, Jay C, Kelly ME, Benowitz NL|
|Journal, Volume, Issue||Clin Pharmacol Ther. 2007 Apr 11; [Epub ahead of print]|
|Major outcome(s)||Vaporization of cannabis is a safe and effective mode of delivery of THC|
Although cannabis may have potential therapeutic value, inhalation of a combustion product is an undesirable delivery system. The aim of the study was to investigate vaporization using the Volcano((R)) device as an alternative means of delivery of inhaled Cannabis sativa. Eighteen healthy inpatient subjects enrolled to compare the delivery of cannabinoids by vaporization to marijuana smoked in a standard cigarette. One strength (1.7, 3.4, or 6.8% tetrahydrocannabinol (THC)) and delivery system was randomly assigned for each of the 6 study days. Plasma concentrations of Delta-9-THC, expired carbon monoxide (CO), physiologic and neuropsychologic effects were the main outcome measures. Peak plasma concentrations and 6-h area under the plasma concentration-time curve of THC were similar. CO levels were reduced with vaporization. No adverse events occurred. Vaporization of cannabis is a safe and effective mode of delivery of THC. Further trials of clinical effectiveness of cannabis could utilize vaporization as a smokeless delivery system.
|Participants||18 healthy subjects|
|Design||Controlled study;Basic research|
|Type of publication||Medical journal|
|Address of author(s)|| 1Community Consortium, Positive Health Program, San Francisco General Hospital, San Francisco, California, USA  2Division of Hematology-Oncology, San Francisco General Hospital, San Francisco, California, USA  3Department of Medicine, University|