Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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Title[Respiratory failure due to delta-9-tetrahydrocannabinol in a tetraplegic patient.]. [Article in German]
Author(s)Neuburger M, Schley M, Schmelz M, Schuepfer G, Konrad C.
Journal, Volume, IssueSchmerz. 2006 Mar 16; [Epub ahead of print]
Major outcome(s)Dronabinol reduced spasticity but worsened respiration
IndicationSpasticity;Spinal cord injuryAbstract
MedicationDelta-9-THC

We report on a patient with an incomplete tetraplegia below C2 who suffered from a post-traumatic abdominal spasticity, spasticity of the legs, and bladder contractions of high intensity. Breathing was possible during the day using accessory respiratory musculature. All standard therapeutic regimes against spasticity failed. Treatment was started with delta-9-tetrahydrocannabinol administered orally in a dosage of 2x2.5 mg/day. The spasticity of the legs and the bladder improved with the treatment. After 3 days, the patient complained about dyspnea and shortness of breath. Treatment with delta-9-tetrahydrocannabinol was discontinued after 5 days but the patient needed ventilatory support for 1 week. After 1 week, spontaneous breathing was possible again. The reasons for respiratory failure in endangered patients during treatment with delta-9-tetrahydrocannabinol could be effects such as sedation, combined treatment with baclofen, muscle weakness, or central nervous effects in the medulla oblongata.

Route(s)Oral
Dose(s)2 x 2,5 mg
Duration (days)3
Participants1 patient with spinal cord injury and tetraplegia
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)Institut fur Anasthesie, Kantonsspital Luzern/Schweiz, , MichaelNeuburger@aol.com.
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