Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




[Back to Overview]  [IACM Homepage]

TitleDelta-9-tetrahydrocannabinol for night-time agitation in severe dementia
Author(s)Walther S, Mahlberg R, Eichmann U, Kunz D
Journal, Volume, IssuePsychopharmacology (Berl) 2006;185(4):524-8.
Major outcome(s)Reduction in night-time agitation in actigraphy and in the neuropsychiatric inventory NPI
IndicationAlzheimer's diseaseAbstract
MedicationDelta-9-THC

RATIONALE: Nighttime agitation occurs frequently in patients with dementia and represents the number one burden on caregivers today. Current treatment options are few and limited due to substantial side effects. OBJECTIVES: The aim of the study was to measure the effect of the cannabinoid dronabinol on nocturnal motor activity. METHODS: In an open-label pilot study, six consecutive patients in the late stages of dementia and suffering from circadian and behavioral disturbances-five patients with ALZHEIMER's disease and one patient with vascular dementia-were treated with 2.5 mg dronabinol daily for 2 weeks. Motor activity was measured objectively using actigraphy. RESULTS: Compared to baseline, dronabinol led to a reduction in nocturnal motor activity (P=0.028). These findings were corroborated by improvements in Neuropsychiatric Inventory total score (P=0.027) as well as in subscores for agitation, aberrant motor, and nighttime behaviors (P<0.05). No side effects were observed. CONCLUSIONS: The study suggests that dronabinol was able to reduce nocturnal motor activity and agitation in severely demented patients. Thus, it appears that dronabinol may be a safe new treatment option for behavioral and circadian disturbances in dementia.

Route(s)Oral
Dose(s)1 x 2,5 mg
Duration (days)14 days
Participants6 patients with severe dementia and agitation/circadian dist
DesignOpen study
Type of publicationMedical journal
Address of author(s)Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Charite Mitte (PUK), Berlin, Germany, sebastian.walther@gef.be.ch
Full text

[Back to Overview]  [IACM Homepage]


up