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cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||The analgesic properties of delta-9-tetrahydrocannabinol and codeine.|
|Author(s)||Noyes R Jr, Brunk SF, Avery DAH, Canter AC|
|Journal, Volume, Issue||Clinical Pharmacology and Therapeutics 1975;18(1):84-89|
|Major outcome(s)||milde analgesic effect; with 20 mg THC strong adverse effects|
The administration of single oral doses of delta-9- tetrahydrocannabinol (THC) to patients with cancer pain demonstrated a mild analgesic effect. At a dose of 20 mg, however, THC induced side effects that would prohibit its therapeutic use including somnolence, dizziness, ataxia, and blurred vision. Alarming adverse reactions were also observed at this dose. THC, 10 mg, was well tolerated and, despite its sedative effect, may analgesic potential.
|Participants||36 cancer patients|
|Type of publication|
|Address of author(s)|