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cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Effect of a nitrogen analog of tetrahydrocannabinol on cancer pain.|
|Author(s)||Staquet M, Gantt C, Machin D.|
|Journal, Volume, Issue||Clin Pharmacol Ther. 1978 Apr;23(4):397-401.|
|Major outcome(s)||NIB was superior to placebo and to secobarbital but is not useful clinically because of the frequency of side effects.|
Two consecutive, randomized, double-blind trials were performed to test the analgesic properties of a synthetic nitrogen analog of tetrahydrocannabinol (NIB). In the first trial, the test preparation was superior to placebo and approximately equivalent to 50 mg of codeine phosphate. In the second study, the tetrahydrocannabinol analog was superior to placebo and to 50 mg secobarbital. NIB is not useful clinically because of the frequency of side effects.
|Participants||45 cancer patients|
|Type of publication||Medical journal|
|Address of author(s)|