Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleDose ranging evaluation of the antiemetic efficacy and toxicity of intramuscular levonantradol in cancer subjects with chemotherapy-induced emesis.
Author(s)Stambaugh JE Jr, McAdams J, Vreeland F.
Journal, Volume, IssueInternational Journal of Clinical Pharmacology Research 1984 Nov-Dec;24(11-12):480-5.
Major outcome(s)Levonantradol more effective than placebo
IndicationCancer chemotherapyAbstract
MedicationOther cannabinoids

A phase II double-blind placebo-controlled, randomized dose-ranging trial was undertaken to determine the antiemetic efficacy and toxicity of the synthetic cannabinoid levonantradol at doses of 0.5, 1.0, 1.5, and 2.0 mg. Intramuscular levonantradol was prophylactically administered in random dosing to 20 subjects with a documented history of refractory emesis due to chemotherapy in advanced cancer. The selected dose was administered prior to the chemotherapy and was serially repeated over 12 hours, and efficacy and toxicity data were evaluated for 24 hours. Significant (P less than 0.01) antiemetic activity over placebo was observed with all doses of levonantradol administered, and a dose-effect response was not observed. Doses up to 2.0 mg were well tolerated, and observed toxicity increased with increased doses and with repeated dosing. Psychomimetic effects were mild and tolerable, and the limiting side effects were somnolence and hypotension.

Route(s)
Dose(s)0.5- 2.0 mg
Duration (days)
ParticipantsPatients undergoing cancer chemotherapy
DesignControlled study
Type of publicationMedical journal
Address of author(s)
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