Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleDouble-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.
Author(s)Steele N, Gralla RJ, Braun DW Jr, Young CW.
Journal, Volume, IssueCancer Treatment Report 1980 Feb-Mar;64(2-3):219-24.
Major outcome(s)Both nabilone and prochlorperazine produced antiemetic effects
IndicationCancer;Cancer chemotherapyAbstract
MedicationNabilone

The antiemetic effect of oral nabilone, a synthetic cannabinoid, given at a dose of 2 mg every 12 hours was compared to oral slow-release capsules of prochlorperazine given at a dose of 10 mg every 12 hours by a double-blind crossover method in 37 patients receiving cancer chemotherapy. Patients received one of the following as the primary emetic stimulus: high-dose cis-dichlorodiammineplatinum(II) (DDP), low-dose DDP, mechlorethamine, streptozotocin, actinomycin D, or DTIC. Although results varied according to strength of emetic stimulus received, both nabilone and prochlorperazine appeared to produce antiemetic effects. Eighteen of the 37 patients achieved a complete or partial elimination of symptoms: seven with nabilone alone, three with prochlorperazine alone, and eight with each drug. Nabilone appeared to be the more effective antiemetic for patients who received chemotherapy agents other than high dose DDP; it was equivalent to prochlorperazine for those who did receive high-dose DDP. Side effects from prochlorperazine were limited to mild drowsiness occurring among 35% of the patients. The side effects from nabilone were drowsiness and dizziness which occurred frequently and were dose-limiting in 25% of patients.

Route(s)Oral
Dose(s)4 mg
Duration (days)
Participants37 patients receiving cancer chemotherapy
DesignControlled study
Type of publicationMedical journal
Address of author(s)
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