Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleNabilone: an effective antiemetic in patients receiving cancer chemotherapy.
Author(s)Einhorn LH, Nagy C, Furnas B, Williams SD.
Journal, Volume, IssueJ Clin Pharmacol. 1981 Aug-Sep;21(8-9 Suppl):64S-69S.
Major outcome(s)Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting.
IndicationNausea/vomiting;Cancer;Cancer chemotherapyAbstract
MedicationNabilone

Eighty evaluable patients receiving chemotherapy were entered on a random prospective double-blind study to evaluate the effectiveness of nabilone, a synthetic cannabinoid, compared to prochlorperazine. Most of these patients received cisplatin, a drug that universally produces severe nausea and vomiting, as part of a combination chemotherapy regimen. The patients served as their own controls, receiving either nabilone or prochlorperazine during two consecutive treatment courses with the identical chemotherapy. Side effects consisting of hypotension and lethargy were more pronounced with nabilone. Toxicity, in general, did not preclude antiemetic treatment and in no way interfered with chemotherapy. Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting. Of these 60 patients, 46 required further chemotherapy and continued taking nabilone as the antiemetic of choice.

Route(s)Oral
Dose(s)
Duration (days)
ParticipantsEighty patients receiving chemotherapy
DesignControlled study
Type of publicationMedical journal
Address of author(s)
Full text

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