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|Title||Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.|
|Author(s)||Crawford SM, Buckman R.|
|Journal, Volume, Issue||Med Oncol Tumor Pharmacother. 1986;3(1):39-42.|
|Major outcome(s)||No difference between nabilone and metoclopramide|
Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg-1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.
|Dose(s)||1 mg 8 hourly|
|Participants||32 patients treated with cisplatin|
|Type of publication||Medical journal|
|Address of author(s)||Department of Medical Oncology, Charing Cross Hospital, London W6 8RF; Department of Oncology, University College Hospital, London WC1, U.K.|