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Title | Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study. |
Author(s) | Crawford SM, Buckman R. |
Journal, Volume, Issue | Med Oncol Tumor Pharmacother. 1986;3(1):39-42. |
Major outcome(s) | No difference between nabilone and metoclopramide |
|
Indication | Nausea/vomiting;Cancer;Cancer chemotherapy | Abstract |
Medication | Nabilone | Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg-1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs. |
Route(s) | Oral |
Dose(s) | 1 mg 8 hourly |
Duration (days) | |
Participants | 32 patients treated with cisplatin |
Design | Controlled study |
Type of publication | Medical journal |
Address of author(s) | Department of Medical Oncology, Charing Cross Hospital, London W6 8RF; Department of Oncology, University College Hospital, London WC1, U.K. |
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