Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleNabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.
Author(s)Crawford SM, Buckman R.
Journal, Volume, IssueMed Oncol Tumor Pharmacother. 1986;3(1):39-42.
Major outcome(s)No difference between nabilone and metoclopramide
IndicationNausea/vomiting;Cancer;Cancer chemotherapyAbstract
MedicationNabilone

Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg-1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.

Route(s)Oral
Dose(s)1 mg 8 hourly
Duration (days)
Participants32 patients treated with cisplatin
DesignControlled study
Type of publicationMedical journal
Address of author(s)Department of Medical Oncology, Charing Cross Hospital, London W6 8RF; Department of Oncology, University College Hospital, London WC1, U.K.
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