On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers|
|Author(s)||Greenberg HS, Werness SAS, Pugh JE, Andrus RO, Anderson DJ, Domino EF|
|Journal, Volume, Issue||Clinical Pharmacology and Therapeutics 1994;55:324-328|
|Major outcome(s)||Cannabis reduced posture and balance in patients with MS|
A double-blind randomised placebo-controlled study of inhaled marijuana smoke on postural responses was performed in 10 adult patients with spastic multiple sclerosis (MS) and 10 normal volunteers matched as closely as possible for age, sex, and weight. A computer-controlled dynamic posturographic platform with a video line scan camera measured shoulder displacement in response to pseudorandom platform movements. Premarijuana smoking patient tracking was inferior to that of the normal volunteers as indicated by the higher noise variance of the former. Smoking one marijuana cigarette containing 1.54% Delta-9-tetrahydrocannabinol increased postural tracking error in both the patients and normal control subjects with both eyes open and closed; this untoward effect was greatest for the patients. The tracking error was also accompanied by a decrease in response speed for the patients with their eyes closed. Marijuana smoking further impairs posture and balance in patients with spastic MS.
|Dose(s)||marijuana cigarette containing 1.54% Delta-9-tetrahydrocannabinol|
|Participants||10 MS patients, 10 normal volunteers|
|Type of publication||Medical journal|
|Address of author(s)|