Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleShort-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers
Author(s)Greenberg HS, Werness SAS, Pugh JE, Andrus RO, Anderson DJ, Domino EF
Journal, Volume, IssueClinical Pharmacology and Therapeutics 1994;55:324-328
Major outcome(s)Cannabis reduced posture and balance in patients with MS
IndicationMultiple sclerosisAbstract
MedicationCannabis

A double-blind randomised placebo-controlled study of inhaled marijuana smoke on postural responses was performed in 10 adult patients with spastic multiple sclerosis (MS) and 10 normal volunteers matched as closely as possible for age, sex, and weight. A computer-controlled dynamic posturographic platform with a video line scan camera measured shoulder displacement in response to pseudorandom platform movements. Premarijuana smoking patient tracking was inferior to that of the normal volunteers as indicated by the higher noise variance of the former. Smoking one marijuana cigarette containing 1.54% Delta-9-tetrahydrocannabinol increased postural tracking error in both the patients and normal control subjects with both eyes open and closed; this untoward effect was greatest for the patients. The tracking error was also accompanied by a decrease in response speed for the patients with their eyes closed. Marijuana smoking further impairs posture and balance in patients with spastic MS.

Route(s)Inhalation
Dose(s)marijuana cigarette containing 1.54% Delta-9-tetrahydrocannabinol
Duration (days)
Participants10 MS patients, 10 normal volunteers
DesignControlled study
Type of publicationMedical journal
Address of author(s)
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