Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleSafety, tolerability, and efficacy of orally administered cannabinoids in MS.
Author(s)Killestein J, Hoogervorst EL, Reif M, Kalkers NF, Van Loenen AC, Staats PG, Gorter RW, Uitdehaag BM, Polman CH
Journal, Volume, IssueNeurology. 2002 May 14;58(9):1404-7.
Major outcome(s)Compared with placebo, neither THC nor plant-extract treatment reduced spasticity.
IndicationSpasticity;Multiple sclerosisAbstract
MedicationCannabis;Delta-9-THC

The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.

Route(s)Oral
Dose(s)2 x 2,5 until 2 x 5 mg
Duration (days)
Participants16 patients with MS
DesignControlled study
Type of publicationMedical journal
Address of author(s)Department of Neurology, VU Medical Center, Amsterdam, the Netherlands. J.Killestein@vumc.nl
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