Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleRandomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia.
Author(s)Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM
Journal, Volume, IssueMov Disord. 2002 Jan;17(1):145-9.
Major outcome(s)No significant reduction in dystonia following treatment with nabilone
IndicationDystoniaAbstract
MedicationNabilone

Cannabis may have medicinal uses in a variety of diseases. The neural mechanisms underlying dystonia involve abnormalities within the basal ganglia-in particular, overactivity of the lateral globus pallidus (GPl). Cannabinoid receptors are located presynaptically on GABA terminals within the GPi, where their activation reduces GABA reuptake. Cannabinoid receptor stimulation may thus reduce overactivity of the GPl and thereby reduce dystonia. A double-blind, randomised, placebo-controlled, crossover study using the synthetic cannabinoid receptor agonist nabilone in patients with generalised and segmental primary dystonia showed no significant reduction in dystonia following treatment with nabilone.

Route(s)Oral
Dose(s)
Duration (days)
Participants13 Patients with dystonia
DesignControlled study
Type of publicationMedical journal
Address of author(s)Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom. shfox@hotmail.com
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