On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia.|
|Author(s)||Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM|
|Journal, Volume, Issue||Mov Disord. 2002 Jan;17(1):145-9.|
|Major outcome(s)||No significant reduction in dystonia following treatment with nabilone|
Cannabis may have medicinal uses in a variety of diseases. The neural mechanisms underlying dystonia involve abnormalities within the basal ganglia-in particular, overactivity of the lateral globus pallidus (GPl). Cannabinoid receptors are located presynaptically on GABA terminals within the GPi, where their activation reduces GABA reuptake. Cannabinoid receptor stimulation may thus reduce overactivity of the GPl and thereby reduce dystonia. A double-blind, randomised, placebo-controlled, crossover study using the synthetic cannabinoid receptor agonist nabilone in patients with generalised and segmental primary dystonia showed no significant reduction in dystonia following treatment with nabilone.
|Participants||13 Patients with dystonia|
|Type of publication||Medical journal|
|Address of author(s)||Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom. firstname.lastname@example.org|