Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleDelta-9-THC in the treatment of spasticity associated with multiple sclerosis.
Author(s)Ungerleider JT, Andyrsiak T, Fairbanks L, Ellison GW, Myers LW
Journal, Volume, IssueAdvances in Alcohol and Substance Abuse 1987;7(1):39-50
Major outcome(s)significant subjective improvement in spasticity at doses of 7.5 mg and above; no objective improvement
IndicationMultiple sclerosis; SpasticityAbstract

Marijuana is reported to decrease spasticity in patients with multiple sclerosis. This is a double blind, placebo controlled, crossover clinical trial of delta-9-THC in 13 subjects with clinical multiple sclerosis and spasticity. Subjects received escalating doses of THC in the range of 2.5-15 mg., five days of THC and five days of placebo in randomized order, divided by a two-day washout period. Subjective ratings of spasticity and side effects were completed and semiquantitative neurological examinations were performed. At doses greater than 7.5 mg there was significant improvement in patient ratings of spasticity compared to placebo. These positive findings in a treatment failure population suggest a role for THC in the treatment of spasticity in multiple sclerosis.

Dose(s)2.5-15 mg once or twice daily
Duration (days)5
Participants13 patients with multiple sclerosis
DesignControlled study
Type of publication
Address of author(s)Department of Psychiatry, U.C.L.A. School of Medicine 90024, USA
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