On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Safety, tolerability, and efficacy of orally administered cannabinoids in MS.|
|Author(s)||Killestein J, Hoogervorst EL, Reif M, Kalkers NF, Van Loenen AC, Staats PG, Gorter RW, Uitdehaag BM, Polman CH|
|Journal, Volume, Issue||Neurology. 2002 May 14;58(9):1404-7.|
|Major outcome(s)||Compared with placebo, neither THC nor plant-extract treatment reduced spasticity.|
The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse events were more common with plant-extract treatment. Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. Both THC and plant-extract treatment worsened the participant's global impression.
|Dose(s)||2 x 2,5 until 2 x 5 mg|
|Participants||16 patients with MS|
|Type of publication||Medical journal|
|Address of author(s)||Department of Neurology, VU Medical Center, Amsterdam, the Netherlands. J.Killestein@vumc.nl|