Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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Diagnosis Title Author(s) Year Medication(s) Design Major outcome(s)
Show Multiple sclerosis; Spinal cord injury; Spasticity; Pain The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. Brenneisen R, Egli A, Elsohly MA, Henn V, Spiess Y 1996 Delta-9-THC improvement of joint function and ability to walk; in 1 patient additional alleviation of pain
Show Spasticity Effective treatment of spasticity using dronabinol in pediatric palliative care. Kuhlen M, Hoell JI, Gagnon G, Balzer S, Oommen PT, Borkhardt A, Janßen G. 2016 Delta-9-THC In the majority of pediatric palliative patients the treatment with dronabinol showed promising effects in treatment resistant spasticit.
Show Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure. De Sousa Fernandes Perna EB, Theunissen EL, Kuypers KP, Toennes SW, Ramaekers JG. 2016 Cannabis Subjective aggression significantly increased following aggression exposure in all groups while being sober.
Show Anxiety Association of cannabis use with the development of elevated anxiety symptoms in the general population: a meta-analysis Twomey CD. 2017 Cannabis No relevant association between cannabis use and anxiety in the general population
Show Cancer;Pain Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain Lichtman AH et al. 2018 Other cannabinoids Low effects of a cannabis extract in cancer patients in a large controlled study
Show Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis Scott JC et al. 2018 Cannabis Effects of cannabis on cognitive performance in adolescents are small
Show Self-initiated use of topical cannabidiol oil for epidermolysis bullosa Chelliah MP, Zinn Z, Khuu P, Teng JMC 2018 Cannabidiol
Show Cancer Current natural therapies in the treatment against glioblastoma. Erices JI, Torres Á, Niechi I, Bernales I, Quezada C. 2018 Cannabis Cannabinoids may be helpful in glioblastoma
Show Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans Azar S. et al. 2018 Other cannabinoids Endocannabinoid levels in obese patients were reduced after surgery against obesity
Show Multiple sclerosis; Spasticity Delta-9-THC in the treatment of spasticity associated with multiple sclerosis. Ungerleider JT, Andyrsiak T, Fairbanks L, Ellison GW, Myers LW 1987 Delta-9-THC Controlled study significant subjective improvement in spasticity at doses of 7.5 mg and above; no objective improvement
Show Multiple sclerosis; Spasticity; Ataxia Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. Meinck HM, Schönle PW, Conrad B 1989 Cannabis Controlled study improvement of tremor, spasticity and ataxia
Show Cancer chemotherapy; Nausea/vomiting Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. Sallan SE, Cronin C, Zelen M, Zinberg NE 1980 Delta-9-THC Controlled study no nausea and vomiting in 36 of 79 courses of chemotherapy with THC compared to 16 of 78 courses in patients who received prochlorperazine; improved appetite with THC
Show Cancer chemotherapy; Nausea/vomiting Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. Sallan SE, Zinberg NE, Frei E 3d 1975 Delta-9-THC Controlled study for patients completing the study there were 5 complete responses (no vomiting) and 7 partial responses (50% decrease of vomiting) of overall 15 courses
Show Nausea/vomiting;Cancer;Cancer chemotherapy Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo. Frytak S, Moertel CG, O'Fallon JR, Rubin J, Creagan ET, O'Connell MJ, Schutt AJ, Schwartau NW 1979 Delta-9-THC Controlled study THC and PCP equally effective; both better than placebo; THC produced psychic effects in 82%
Show Cancer chemotherapy; Nausea/vomiting Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis. Orr LE, McKernan JF, Bloome B 1980 Delta-9-THC Controlled study no nausea and no vomiting (complete response) in 73% (40/55 courses) in THC group
Show Spasticity Treatment of human spasticity with delta 9-tetrahydrocannabinol. Petro DJ, Ellenberger C Jr 1981 Delta-9-THC Controlled study reduced spasticity with 10 mg THC
Show Multiple sclerosis; Tremor Tetrahydrocannabinol for tremor in multiple sclerosis. Clifford DB 1983 Delta-9-THC Controlled study 2 patients with objective improvement, 5 with subjective improvement
Show Spasticity;Spinal cord injury;Pain Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. Maurer M, Henn V, Dittrich A, Hofmann A 1990 Delta-9-THC Controlled study THC and codeine reduced pain; THC reduced spasticity
Show Multiple sclerosis; Spasticity Nabilone in the treatment of multiple sclerosis. Martyn CN, Illis LS, Thom J 1995 Nabilone Controlled study improvement of muscle spasms and frequency of nocturia
Show Pain Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. Berman JS, Symonds C, Birch R. 2004 Cannabis;Delta-9-THC Controlled study Significant pain relief and improvement of sleep
Show Cancer; Pain Analgesic effect of delta-9-tetrahydrocannabinol. Noyes R Jr, Brunk SF, Baram DA, Canter A 1975 Delta-9-THC Controlled study pain relief with 15-20 mg THC
Show Cancer; Pain The analgesic properties of delta-9-tetrahydrocannabinol and codeine. Noyes R Jr, Brunk SF, Avery DAH, Canter AC 1975 Delta-9-THC Controlled study milde analgesic effect; with 20 mg THC strong adverse effects
Show Pain Pain relief with oral cannabinoids in familial Mediterranean fever. Holdcroft A, Smith M, Jacklin A, Hodgson H, Smith B, Newton M, Evans F 1997 Cannabis Controlled study reduction of need for morphin
Show Cancer; Appetite loss/weight loss; Depression Regelson W, Butler JR, Schulz J, Kirk T, Peek L, Green ML, Zalis MO 1976 Delta-9-THC Controlled study weight gain with THC; weight los with placebo
Show HIV/AIDS; Appetite loss/weight loss; Depression Dronabinol stimulates appetite and causes weight gain in HIV patients. Plasse T, Conant M, Gorter R, Shepard KV 1992 Delta-9-THC Controlled study increase in appetite, trend toward weight gain
Show Appetite loss/weight loss;HIV/AIDS;Depression Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. Beal JE, Olson R, Laubenstein L, Morales JO, Bellman P, Yangco B, Lefkowitz L, Plasse TF, Shepard KV 1995 Delta-9-THC Controlled study increased appetite; improvement in mood; stabel weight
Show Nausea/vomiting;Cancer;Cancer chemotherapy A prospective evaluation of delta-9-tetrahydrocannabinol as an antiemetic in patients receiving adriamycin and cytoxan chemotherapy. Chang AE, Shiling DJ, Stillman RC, Goldberg NH, Seipp CA, Barofsky I, Rosenberg 1981 Delta-9-THC Controlled study no significant reduction of the number of vomiting, volume of emesis, degree of nausea, or duration of nausea
Show Nausea/vomiting;Cancer;Cancer chemotherapy Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation. Chang AE, Shiling DJ, Stillman RC, Goldberg NH, Seipp CA, Barofsky I, Simon RM, Rosenberg SA. 1979 Delta-9-THC Controlled study 14 of 15 patients had decreased vomiting and nausea
Show Nausea/vomiting;Cancer;Cancer chemotherapy The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy. Colls BM, Ferry DG, Gray AJ, Harvey VJ, McQueen EG. 1980 Delta-9-THC Controlled study tetrahydrocannabinol given by mouth has an antiemetic effect of approximately the same order as thiethylperazine and metoclopramide
Show Nausea/vomiting;Cancer;Cancer chemotherapy Antiemetic therapy: a review of recent studies and a report of a random assignment trial comparing metoclopramide with delta-9-tetrahydrocannabinol. Gralla RJ, Tyson LB, Bordin LA, Clark RA, Kelsen DP, Kris MG, Kalman LB, Groshen S 1984 Delta-9-THC Controlled study Poorer antiemetic control and more side effects with dronabinol than with the metoclopramide, both better than placebo
Show Nausea/vomiting;Cancer;Cancer chemotherapy Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA 1979 Delta-9-THC Controlled study dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently)
Show Nausea/vomiting;Cancer;Cancer chemotherapy Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting. Lane M, Vogel CL, Ferguson J, Krasnow S, Saiers JL, Hamm J 1991 Delta-9-THC Controlled study prochlorperazine better than THC, both drugs combined better than both alone
Show Nausea/vomiting;Cancer;Cancer chemotherapy Randomized double blind comparison of delta-9-tetrahydroicannabinol (THC) and marijuana as chemotherapy antiemetics. Levitt M, Faiman C, Hawks R, Wilson A 1984 Cannabis;Delta-9-THC Controlled study 9 patients no preference; 7 preferred oral THC, 4 preferred marijuana cigarettes (double-blind, double dummy crossover study)
Show Nausea/vomiting;Cancer;Cancer chemotherapy Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics. Levitt M, Wilson A, Bowman D, Faiman C, Kemel S, Krepart G 1981 Delta-9-THC Controlled study THC 15 mg was the most effective against vomiting, prochlorperazine was the most effective antinauseant
Show Nausea/vomiting;Cancer;Cancer chemotherapy Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy McCabe M, Smith FP, Goldberg D, Macdonald J, Woolley PV, Warren R 1988 Delta-9-THC Controlled study THC decreased nausea and vomiting in 23 of 36 (64%) patients
Show Parkinson's disease Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study. Carroll CB, Bain PG, Teare L, Liu X, Joint C, Wroath C, Parkin SG, Fox P, Wright D, Hobart J, Zajicek JP. 2004 Cannabis Controlled study Cannabis had no treatment effect on levodopa-induced dyskinesia.
Show Nausea/vomiting;Cancer;Cancer chemotherapy THC or Compazine for the cancer chemotherapy patient--the UCLA study. Part II: Patient drug preference. Ungerleider JT, Sarna G, Fairbanks LA, Goodnight J, Andrysiak T, Jamison K. 1985 Delta-9-THC Controlled study nausea reduction was the main determinant of preference between THC and prochlorperazine
Show Spasticity;Spinal cord injury;Multiple sclerosis;Pain A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. Wade DT, Robson P, House H, Makela P, Aram J. 2003 Cannabis;Delta-9-THC;Cannabidiol Controlled study Pain relief associated with both THC and CBD was significantly superior to placebo. Impaired bladder control, muscle spasms and spasticity were improved by cannabis in some patients
Show Epilepsy Anticonvulsant effect of cannabidiol. Ames FR, Cridland S 1986 Cannabidiol Controlled study no significant effect in addition to standard medication
Show Glaucoma Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans. Cooler P, Gregg JM 1977 Delta-9-THC Controlled study reduction in intraocular pressure
Show Glaucoma Effects of tetrahydrocannabinol on arterial and intraocular hypertension. Crawford WJ, Merritt JC 1979 Cannabis Controlled study drop in IOP parallel with drop in arterial blood pressure
Show Epilepsy Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R 1980 Cannabidiol Controlled study 4 of the 8 CBD subjects remained almost free of convulsive crises and 3 other patients demonstrated partial improvement
Show Asthma Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects. Gong H Jr, Tashkin DP, Calvarese B 1983 Nabilone Controlled study moderate bronchodilator action in healthy subjects; no difference to placebo in asthmatics
Show Appetite loss/weight loss A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa. Gross H, Ebert MH, Faden VB, Goldberg SC, Kaye WH, Caine ED, Hawks R, Zinberg N 1983 Delta-9-THC Controlled study no significant difference between THC and diazepam
Show Pain Evaluation of intramuscular levonantradol and placebo in acute postoperative pain. Jain AK, Ryan JR, McMahon FG, Smith G. 1981 Other cannabinoids Controlled study significant pain relief compared with placebo
Show Appetite loss/weight loss;Cancer Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study. Jatoi A, Windschitl HE, Loprinzi CL, Sloan JA, Dakhil SR, Mailliard JA, Pundaleeka S, Kardinal CG, Fitch TR, Krook JE, Novotny PJ, Christensen B. 2002 Delta-9-THC Controlled study megestrol acetate was superior to THC
Show Multiple sclerosis;Pain Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial Svendsen KB, Jensen TS, Bach FW 2004 Delta-9-THC Controlled study Significant reduction of pain by THC
Show Glaucoma Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma. Merritt JC, Perry DD, Russell DN, Jones BF 1981 Delta-9-THC Controlled study no effect
Show Parkinson's disease Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study. Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM 2001 Nabilone Controlled study significant reduction of levodopa-induced dyskinesia
Show Nausea/vomiting Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac. Soderpalm AH, Schuster A, de Wit H 2001 Cannabis Controlled study Ondansetron superior to cannabis in reducing nausea and vomiting
Show Spasticity;Multiple sclerosis;Pain;Tremor Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Wade DT, Makela P, Robson P, House H, Bateman C. 2004 Cannabis Controlled study Spasticity scores were significantly reduced by cannabis.
Show Asthma Effects of smoked marijuana in experimentally induced asthma. Tashkin DP, Shapiro BJ, Lee YE, Harper CE 1975 Cannabis Controlled study after experimental induction of acute bronchospasm prompt correction of the bronchospasm with cannabis
Show Appetite loss/weight loss;HIV/AIDS The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative. Timpone JG, Wright DJ, Li N, Egorin MJ, Enama ME, Mayers J, Galetto G 1997 Delta-9-THC Controlled study weight loss with THC, weight gain with megestrol acetate
Show Appetite loss/weight loss;Alzheimer's disease Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. Volicer L, Stelly M, Morris J, McLaughlin J, Volicer BJ 1997 Delta-9-THC Controlled study higher weight gain with THC; reduction of disturbed behaviour with THC
Show Asthma Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. Williams SJ, Hartley JP, Graham JD 1976 Delta-9-THC Controlled study significant broncholdilation with THC; faster action of salbutamol but both drugs equivalent at 1 hour
Show HIV/AIDS Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. Abrams DI, Hilton JF, Leiser RJ, Shade SB, Elbeik TA, Aweeka FT, Benowitz NL, Bredt BM, Kosel B, Aberg JA, Deeks SG, Mitchell TF, Mulligan K, Bacchetti P, McCune JM, Schambelan M 2003 Cannabis;Delta-9-THC Controlled study Cannabis and THC had no significant effect on HI virus load and on CD4+ and CD8+ cell count
Show Spasticity;Multiple sclerosis Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy.Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. Vaney C, Heinzel-Gutenbrunner M, Jobin P, Tschopp F, Gattlen B, Hagen U, Schnelle M, Reif M. 2004 Cannabis Controlled study Significant reduction in spasm frequency in the 37 patients who received at least 90% of the dose.
Show Nausea/vomiting;Cancer;Cancer chemotherapy Comparative trial of the antiemetic effects of THC and haloperidol Neidhart JA, Gagen MM, Wilson HE, Young DC 1981 Delta-9-THC Controlled study THC and haloperidol equally effective
Show Nausea/vomiting;Cancer chemotherapy Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine. Ungerleider JT, Andrysiak T, Fairbanks L, Goodnight J, Sarna G, Jamison K. 1982 Delta-9-THC Controlled study No significant differences between THC and prochlorperazine
Show Asthma Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects. Tashkin DP, Shapiro BJ, Frank IM. 1974 Cannabis;Delta-9-THC;Cannabidiol Controlled study Smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration.
Show Spasticity;Spinal cord injury The treatment of spasticity with D9-tetrahydrocannabinol (D9-THC) in patients with spinal cord injury Hagenbach U, Luz S, Brenneisen R, Mäder M 2003 Delta-9-THC Controlled study Significant reduction of spasticity
Show Multiple sclerosis;Pain Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis. Young CA, Rog DJ 2003 Cannabis Controlled study Significant reduction in pain
Show Pain Efficacy of two cannabis-based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial Berman J, Lee J, Cooper M, Cannon A, Sach J, McKerral S, Taggart M, Symonds C, Fishel K, Birch R 2003 Cannabis;Delta-9-THC Controlled study Significant pain relief and improvement of sleep
Show Pain Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial. Karst M, Salim K, Burstein S, Conrad I, Hoy L, Schneider U. 2003 Other cannabinoids Controlled study Significant reduction of pain
Show Glaucoma Effect of marihuana on intraocular and blood pressure in glaucoma. Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SS 1980 Cannabis Controlled study Marihuana inhalation decreased intraocular and blood pressure.
Show Cancer chemotherapy;Glaucoma Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications. Levitt M, Wilson A, Bowman D, Kemel S, Krepart G, Marks V, Schipper H, Thomson G, Weinerman B, Weinerman R 1981 Delta-9-THC Controlled study Patients were remarkably free of adverse physiologic effects.
Show Pain Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlates of the analgesic response. Raft D, Gregg J, Ghia J, Harris L 1977 Delta-9-THC Controlled study No pain relief with THC
Show Pain Effect of benzopyranoperidine, a delta-9-THC congener, on pain. Jochimsen PR, Lawton RL, VerSteeg K, Noyes Jr R 1978 Other cannabinoids Controlled study Bezopyranoperidine was not more effective than placebo
Show Controlled clincal trial of cannabidiol in Huntington's disease. Consroe P, Laguna J, Allender J, Snider S, Stern L, Sandyk R, Kennedy K, Schram K 1991 Cannabidiol Controlled study CBD was neither symptomatically effective nor toxic.
Show Tourette's syndrome Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial. Muller-Vahl KR, Schneider U, Prevedel H, Theloe K, Kolbe H, Daldrup T, Emrich HM. 2003 Delta-9-THC Controlled study Results provide evidence that THC is effective in the treatment of tics.
Show Tourette's syndrome Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial. Muller-Vahl KR, Schneider U, Koblenz A, Jobges M, Kolbe H, Daldrup T, Emrich HM. 2002 Delta-9-THC Controlled study Significant improvement of tics and obsessive-compulsive behavior after treatment with THC.
Show Dystonia Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia. Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM 2002 Nabilone Controlled study No significant reduction in dystonia following treatment with nabilone
Show Spinal cord injury Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients. Hagenbach U, Ghafoor N, Brenneisen R, Luz S, Mäder M. 2001 Delta-9-THC Controlled study Significant improvement of some parameters of bladder function
Show Spasticity;Multiple sclerosis Safety, tolerability, and efficacy of orally administered cannabinoids in MS. Killestein J, Hoogervorst EL, Reif M, Kalkers NF, Van Loenen AC, Staats PG, Gorter RW, Uitdehaag BM, Polman CH 2002 Cannabis;Delta-9-THC Controlled study Compared with placebo, neither THC nor plant-extract treatment reduced spasticity.
Show Multiple sclerosis;Tremor The effect of cannabis on tremor in patients with multiple sclerosis. Fox P, Bain PG, Glickman S, Carroll C, Zajicek J. 2004 Cannabis;Delta-9-THC;Other cannabinoids Controlled study No significant improvement of tremor
Show Pain Lack of analgesic efficacy of oral delta-9-tetrahydrocannabinol in postoperative pain. Buggy DJ, Toogood L, Maric S, Sharpe P, Lambert DG, Rowbotham DJ 2003 Delta-9-THC Controlled study 5 mg was ineffective in reduding postoperative pain.
Show Nausea/vomiting Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol. Ekert H, Waters KD, Jurk IH, Mobilia J, Loughnan P 1979 Delta-9-THC Controlled study THC was effective in reducing nausea and vomiting but not in all patients
Show Spasticity;Multiple sclerosis;Pain Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial. Zajicek J, Fox P, Sanders H, Wright D, Vickery J, Nunn A, Thompson A, on behalf of the UK 2003 Cannabis;Delta-9-THC Controlled study No effect of cannabinoids on spasticity as measured by the Ashworth scale, while patient-reported spasticity and pain decreased.
Show Asthma Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects. Tashkin DP, Reiss S, Shapiro BJ, Calvarese B, Olsen JL, Lodge JW. 1977 Delta-9-THC Controlled study THC effective in healthy subjects and 3 asthmatic subjects; aerosol caused bronchoconstriction in 2 asthmatic subjects
Show Spasticity Effect of Delta-9-THC on EMG Measurements in Human Spasticity Truong XT, Hanigan WC 1986 Delta-9-THC Controlled study THC reduced several types of spastic manifestations
Show Multiple sclerosis Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers Greenberg HS, Werness SAS, Pugh JE, Andrus RO, Anderson DJ, Domino EF 1994 Cannabis Controlled study Cannabis reduced posture and balance in patients with MS
Show Appetite loss/weight loss Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. Foltin RW, Fischman MW, Byrne MF. 1988 Cannabis Controlled study Increases in body weight during periods of active marijuana smoking were greater than predicted by caloric intake alone.
Show Appetite loss/weight loss Behavioral analysis of marijuana effects on food intake in humans. Foltin RW, Fishman MW, Brady JV. 1986 Cannabis Controlled study The administration of two or three active marijuana cigarettes during the social access period increased average daily caloric intake.
Show Nausea/vomiting;Cancer;Cancer chemotherapy Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. Ahmedzai S, Carlyle DL, Calder IT, Moran F. 1983 Nabilone Controlled study Symptom scores were significantly better for patients on nabilone for nausea, retching and vomiting.
Show Nausea/vomiting;Cancer;Cancer chemotherapy Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. Chan HS, Correia JA, MacLeod SM 1987 Nabilone Controlled study Nabilone effective as antiemetic drug for children
Show Nausea/vomiting;Cancer;Cancer chemotherapy Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study. Crawford SM, Buckman R. 1986 Nabilone Controlled study No difference between nabilone and metoclopramide
Show Nausea/vomiting;Cancer;Cancer chemotherapy Nabilone: an alternative antiemetic for cancer chemotherapy. Dalzell AM, Bartlett H, Lilleyman JS. 1986 Nabilone Controlled study Even for young children nabilone is an effective antiemetic, superior to domperidone.
Show Nausea/vomiting;Cancer;Cancer chemotherapy Nabilone: an effective antiemetic in patients receiving cancer chemotherapy. Einhorn LH, Nagy C, Furnas B, Williams SD. 1981 Nabilone Controlled study Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting.
Show Nausea/vomiting;Cancer;Cancer chemotherapy [Randomized comparative trial of a new anti-emetic: nabilone, in cancer patients treated with cisplatin][Article in French] George M, Pejovic MH, Thuaire M, Kramar A, Wolff JP. 1983 Nabilone Controlled study Nabilone, in comparison with chlorpromazine did not significantly reduce the number of vomiting, but most patients preferred nabilone.
Show Nausea/vomiting;Cancer;Cancer chemotherapy Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. Herman TS, Einhorn LH, Jones SE, Nagy C, Chester AB, Dean JC, Furnas B, Williams SD, Leigh SA, Dorr RT, Moon TE. 1979 Nabilone Controlled study When both drugs were compared, both nausea and vomiting episodes were significantly lower in patients given nabilone.
Show Nausea/vomiting;Cancer;Cancer chemotherapy Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy. Niederle N, Schutte J, Schmidt CG. 1986 Nabilone Controlled study Nabilone superior to alizapride.
Show Nausea/vomiting;Cancer;Cancer chemotherapy A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. Niiranen A, Mattson K. 1985 Nabilone Controlled study Nabilone is a moderately effective anti-emetic drug
Show Nausea/vomiting;Cancer;Cancer chemotherapy Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis. Pomeroy M, Fennelly JJ, Towers M. 1986 Nabilone Controlled study Nabilone superior to domperidone
Show Nausea/vomiting A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea. Priestman SG, Priestman TJ, Canney PA. 1987 Nabilone Controlled study Nabilone similar effective as metoclopramide
Show Cancer;Cancer chemotherapy Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis. Steele N, Gralla RJ, Braun DW Jr, Young CW. 1980 Nabilone Controlled study Both nabilone and prochlorperazine produced antiemetic effects
Show Nausea/vomiting;Cancer;Cancer chemotherapy A randomised multicentre single blind comparison of a cannabinoid anti-emetic (levonantradol) with chlorpromazine in patients receiving their first cytotoxic chemotherapy. Hutcheon AW, Palmer JB, Soukop M, Cunningham D, McArdle C, Welsh J, Stuart F, Sangster G, Kaye S, Charlton D, et al. 1983 Other cannabinoids Controlled study 0.5 mg levonantradol was a more effective antiemtic than 25 mg chlorpromazine
Show Cancer chemotherapy Dose ranging evaluation of the antiemetic efficacy and toxicity of intramuscular levonantradol in cancer subjects with chemotherapy-induced emesis. Stambaugh JE Jr, McAdams J, Vreeland F. 1984 Other cannabinoids Controlled study Levonantradol more effective than placebo
Show Nausea/vomiting Randomised clinical trial of levonantradol and chlorpromazine in the prevention of radiotherapy-induced vomiting. Lucraft HH, Palmer MK 1982 Other cannabinoids Controlled study The frequency of vomiting was similar after levonantradol and chlorpromazine.
Show Nausea/vomiting Effect of nabilone on nausea and vomiting after total abdominal hysterectomy. Lewis IH, Campbell DN, Barrowcliffe MP. 1994 Nabilone Controlled study Nabilone and metoclopramide were equally effective in reducing nausea and vomiting
Show Pain A study of levonantradol, a cannabinol derivative, for analgesia in post operative pain. Kantor TG, Hopper M. 1981 Other cannabinoids Controlled study Levonantradol has analgetic activity but may have central nervous system adverse effects in humans.
Show Cancer;Pain Effect of a nitrogen analog of tetrahydrocannabinol on cancer pain. Staquet M, Gantt C, Machin D. 1978 Other cannabinoids Controlled study NIB was superior to placebo and to secobarbital but is not useful clinically because of the frequency of side effects.
Show Cancer;Cancer chemotherapy A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy. Johansson R, Kilkku P, Groenroos M. 1982 Nabilone Controlled study Severity of nausea and number of vomiting ejections and dry retching episodes were significantly less under nabilone.
Show Appetite loss/weight loss;HIV/AIDS Effect of dronabinol on nutritional status in HIV infection. Struwe M, Kaempfer SH, Geiger CJ, Pavia AT, Plasse TF, Shepard KV, Ries K, Evans TG. 1993 Delta-9-THC Controlled study Trends toward weight gain, improved appetite, decreased symptom stress
Show Glaucoma Clinical relevance of cannabis tolerance and dependence. Jones RT, Benowitz NL, Herning RI. 1981 Delta-9-THC Controlled study
Show Cancer;Cancer chemotherapy Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting. Citron ML, Herman TS, Vreeland F, Krasnow SH, Fossieck BE Jr, Harwood S, Franklin R, Cohen MH. 1985 Delta-9-THC;Other cannabinoids Controlled study Levonantradol appears to be at least as effective an antiemetic as THC ; well-tolerated side-effects.
Show Parkinson's disease The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease (PD). Sieradzan KA, Fox SH, Dick J, Brotchie JM. 1998 Nabilone Controlled study Activation of cannabinoid receptors can reduce L-DOPA-induced dyskinesia in man without aggravating parkinsonism.
Show Spasticity The effect of delta-9-THC on human spasticity. Hanigan WC, Destree R, Truong XT. 1986 Delta-9-THC Controlled study Delta-9-THC proved clinically beneficial in two of five patients with intractable spasticity.
Show Nausea/vomiting;Cancer;Cancer chemotherapy A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting. Jones SE, Durant JR, Greco FA, Robertone A. 1982 Nabilone Controlled study Nabilone is an effective antiemetic agent for chemotherapy-induced nausea and vomiting.
Show Pain Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Wallace M, Schulteis G, Atkinson JH, Wolfson T, Lazzaretto D, Bentley H, Gouaux B, Abramson I. 2007 Cannabis Controlled study A medium dose of cannabis reduced pain, while a high dose increased pain induced by capsaicin
Show Spasticity;Multiple sclerosis Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up. Zajicek JP, Sanders HP, Wright DE, Vickery PJ, Ingram WM, Reilly SM, Nunn AJ, Teare LJ, Fox PJ, Thompson AJ. 2005 Cannabis;Delta-9-THC Controlled study Spasticity in the Ashworth scale was significantly reduced by an average of 1.82 in the THC group; no significant reduction in the cannabis group
Show Pain Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial. Nurmikko TJ, Serpell MG, Hoggart B, Toomey PJ, Morlion BJ, Haines D. 2007 Cannabis Controlled study Significant improvement in pain by cannabis
Show Pain Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study. Frank B, Serpell MG, Hughes J, Matthews JN, Kapur D. 2008 Nabilone Controlled study Nabilone as effective as hydrocodeine in treating neuropatic pain
Show Epilepsy Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R 1980 Cannabidiol Controlled study 4 of the 8 CBD subjects remained almost free of convulsive crises and 3 other patients demonstrated partial improvement
Show Multiple sclerosis Randomised controlled study of cannabis-based medicine (Sativex®) in patients suffering from multiple sclerosis associated detrusor overactivity de Ridder D, Constantinescu CS,Fowler C, Kavia R, Sarantis N. 2006 Cannabis Controlled study A significant reduction in the number of voids per day and during the night.
Show Spasticity;Multiple sclerosis A randomised controlled study of Sativex® in patients with symptoms of spasticity due to multiple sclerosis Collin C, Ambler Z, Kent R, McCalla R. 2006 Cannabis Controlled study Spasticity of patients who received cannabis and complied with the study protocol was significantly reduced compared to placebo.
Show Spasticity;Multiple sclerosis Cannabis-based medicinal extract (Sativex) produced significant improvements in a subjective measure of spasticity which were maintained on long-term treatment with no evidence of tolerance. Robson P, Wade D, Makela P, House H, Bateman C 2005 Cannabis Controlled study Beneficial effects of cannabis on spasticity in MS seem to be maintained over long-term treatment, with no evidence of tolerance.
Show Psychosis/schizophrenia Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. 2012 Cannabidiol Controlled study CBD was as effective as amisulpride, a standard antipsychotic
Show Multiple sclerosis;Pain;Spasticity Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. Corey-Bloom J, Wolfson T, Gamst A, Jin S, Marcotte TD, Bentley H, Gouaux B. 2012 Cannabis Controlled study Smoked cannabis was superior to placebo in reducing spasticity and pain.
Show HIV/AIDS;Pain Smoked cannabis therapy for HIV-related painful peripheral neuropathy: results of a randomized, placebo-controlled clinical trial. Abrams DI, Jay CA, Vizoso H, Shade SB, Reda H, Press S, Kelly ME, Rowbotham M, Petersen K 2005 Cannabis Controlled study Smoked cannabis is effective in reducing HIV-related neuropathic pain
Show Pain Standardized cannabis extract in the treatment of postherpetic neuralgia – a randomized, double-blind, placebo-controlled cross-over study. Ernst G, Denke C, Reif M, Schnelle M, Hagmeister H 2005 Cannabis Controlled study Cannabis did not reduce pain
Show Multiple sclerosis;Pain Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Rog DJ, Nurmikko TJ, Friede T, Young CA. 2005 Cannabis Controlled study Cannabis is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain
Show Pain Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. Roberts JD, Gennings C, Shih M. 2006 Delta-9-THC Controlled study There was a synergistic effect between THC and morphine on the affective component of pain but not on the sensory component
Show Pain [(9)-tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain.] [Article in German] Seeling W, Kneer L, Buchele B, Gschwend JE, Maier L, Nett C, Simmet T, Steffen P, Schneider M, Rockemann M. 2006 Delta-9-THC Controlled study Application of THC reduced the need of an opioid to treat postoperative pain but the difference to placebo was not significant
Show Pain A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. Holdcroft A, Maze M, Dore C, Tebbs S, Thompson S. 2006 Cannabis Controlled study The optimal dose was 10 mg Cannador, effectively reducing postoperative pain without serious side effects.
Show Multiple sclerosis The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS). Freeman RM, Adekanmi O, Waterfield MR, Waterfield AE, Wright D, Zajicek J. 2006 Cannabis;Delta-9-THC Controlled study Cannabis and dronabinol caused a significant reduction in incontinence
Show Appetite loss/weight loss;HIV/AIDS Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep. Haney M, Gunderson EW, Rabkin J, Hart CL, Vosburg SK, Comer SD, Foltin RW 2007 Cannabis;Delta-9-THC Controlled study THC and cannabis caused an increase in caloric intake and weight
Show Nausea/vomiting;Cancer;Cancer chemotherapy Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting. Meiri E, Jhangiani H, Vredenburgh JJ, Barbato LM, Carter FJ, Yang HM, Baranowski V. 2007 Delta-9-THC Controlled study Dronabinol was as effective as ondansetron in reducing nausea and vomiting. Combination therapy was not more effective.
Show Spasticity;Multiple sclerosis Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis Collin C, Davies P, Mutiboko IK, Ratcliffe S, for the Sativex Spasticity in MS Study Group 2007 Cannabis Controlled study Significantly reduction in spasticity
Show Appetite loss/weight loss;Cancer Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-in-Cachexia-Study-Group Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny T. 2006 Cannabis;Delta-9-THC Controlled study No difference between cannabis, THC and placebo
Show Pain [Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain - a randomized controlled trial.] [Article in German] Pinsger M, Schimetta W, Volc D, Hiermann E, Riederer F, Polz W. 2006 Nabilone Controlled study Nabilone caused a significant reduction in pain and improvement of quality of life.
Show Pain Effects of nabilone, a synthetic cannabinoid, on postoperative pain. Beaulieu P. 2006 Nabilone Controlled study No pain reduction with nabilone.
Show HIV/AIDS;Pain Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial. Abrams DI, Jay CA, Shade SB, Vizoso H, Reda H, Press S, Kelly ME, Rowbotham MC, Petersen KL. 2007 Cannabis Controlled study Smoked cannabis was well tolerated and effectively relieved chronic neuropathic pain from HIV-associated sensory neuropathy.
Show Multiple sclerosis;Pain Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial. Wissel J, Haydn T, Muller J, Brenneis C, Berger T, Poewe W, Schelosky LD. 2006 Nabilone Controlled study Significant reduction of pain
Show Glaucoma Effect of Sublingual Application of Cannabinoids on Intraocular Pressure: A Pilot Study. Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ. 2006 Delta-9-THC;Cannabidiol Controlled study Significant reduction of intraocular pressure
Show Pain A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain. Wilsey B, Marcotte T, Tsodikov A, Millman J, Bentley H, Gouaux B, Fishman S. 2008 Cannabis Controlled study Significant improvement of pain
Show Appetite loss/weight loss;HIV/AIDS;Alzheimer's disease Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood. Haney M, Rabkin J, Gunderson E, Foltin RW. 2005 Cannabis;Delta-9-THC Controlled study THC and cannabis cause increased caloric intake
Show Pain Nabilone for the treatment of pain in fibromyalgia. Skrabek RQ, Galimova L, Ethansand Daryl K. 2007 Nabilone Controlled study Significant reduction of pain and improvement of quality of life with nabilone
Show Spasticity;Spinal cord injury;Pain Sativex® in the Treatment of Central Neuropathic Pain due to Spinal Cord Injury: A Randomised Controlled Study Berman J & the Sativex Spinal Cord Injury Study Group, Bosworth T2 Guy G & Stott C. 2007 Cannabis Controlled study primary outcome mean NRS 11 poitn pain scale - nod difference - BPI secondary ourcome benefit - significant at p<0.032
Show Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. D'Souza DC, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. 2005 Delta-9-THC Controlled study THC is associated with transient exacerbation in core psychotic and cognitive deficits in schizophrenia.
Show Pain The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions. Naef M, Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Zbinden A, Brenneisen R. 2003 Delta-9-THC Controlled study No effect of THC on experimental pain in healthy subjects
Show Dependency/withdrawal Marijuana withdrawal in humans: effects of oral THC or divalproex. Haney M, Hart CL, Vosburg SK, Nasser J, Bennett A, Zubaran C, Foltin RW. 2004 Delta-9-THC Controlled study THC abolished withdrawal symptoms
Show Pain Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies. Notcutt W, Price M, Miller R, Newport S, Phillips C, Simmons S, Sansom C. 2004 Cannabis Controlled study Improvement of pain
Show Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. Nicholson AN, Turner C, Stone BM, Robson PJ. 2004 Cannabis;Delta-9-THC;Cannabidiol Controlled study THC had sedative effects, CBD had alerting effects
Show Pain Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. 2006 Cannabis Controlled study Cannabis produced improvements in pain and sleep
Show Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial. Maas AI, Murray G, Henney H 3rd, Kassem N, Legrand V, Mangelus M, Muizelaar JP, Stocchetti N, Knoller N; Pharmos TBI investigators. 2006 Other cannabinoids Controlled study No effect of dexanabinol
Show Anxiety The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety. Fabre LF, McLendon D. 1981 Nabilone Controlled study Dramatic improvement in anxiety
Show Pain Lack of analgesia by oral standardized cannabis extract on acute inflammatory pain and hyperalgesia in volunteers. Kraft B, Frickey NA, Kaufmann RM, Reif M, Frey R, Gustorff B, Kress HG. 2008 Cannabis Controlled study The cannabis extract showed no analgesic effect in acute experimental pain
Show Pain Analgesic and antihyperalgesic effects of nabilone on experimental heat pain. Redmond WJ, Goffaux P, Potvin S, Marchand S. 2008 Nabilone Controlled study Nabilone did not reduce experimental heat pain
Show Anxiety Single-dose study of nabilone in anxious volunteers. Glass RM, Uhlenhuth EH, Hartel FW, Schuster CR, Fischman MW. 1981 Nabilone Controlled study Antianxiety effects in 2 of the 8 subjects
Show Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study. Esfandyari T, Camilleri M, Ferber I, Burton D, Baxter K, Zinsmeister AR. 2006 Delta-9-THC Controlled study THC retarded gastric emptying
Show Pain Evaluation of herbal cannabis characteristics by medical users: a randomized trial. Ware MA, Ducruet T, Robinson AR. 2006 Cannabis Controlled study Medical cannabis users can appreciate differences in herbal cannabis products
Show Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study. Esfandyari T, Camilleri M, Busciglio I, Burton D, Baxter K, Zinsmeister AR. 2007 Delta-9-THC Controlled study THC relaxes the colon and reduces postprandial colonic motility
Show Cannabis improves night vision: A pilot study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif Mountains of Northern Morocco. Russo EB, Merzouki A, Molero Mesa J, Frey KA, Bach PJ. 2004 Cannabis;Delta-9-THC Controlled study Oral THC and smoking of cannabis improved night vision
Show Pain Nabilone for the treatment of pain in fibromyalgia. Skrabek RQ, Galimova L, Ethans K, Perry D. 2008 Nabilone Controlled study Nabilone improved symptoms and was well-tolerated
Show Pain Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy. Narang S, Gibson D, Wasan AD, Ross EL, Michna E, Nedeljkovic SS, Jamison RN. 2008 Delta-9-THC Controlled study THC reduced pain
Show Nausea/vomiting;Cancer Tetrahydrocannabinol vs. prochlorperazine. The effects of two antiemetics on patients undergoing radiotherapy. Ungerleider JT, Andrysiak TA, Fairbanks LA, Tesler AS, Parker RG. 1984 Delta-9-THC Controlled study THC was slightly superior to prochlorperazine
Show Pain Antinociceptive, subjective and behavioral effects of smoked marijuana in humans. Greenwald MK, Stitzer ML. 2000 Cannabis Controlled study Cannabis produced dose-dependent antinociception
Show Pain Marihuana and pain. Hill SY, Schwin R, Goodwin DW, Powell B. 1974 Cannabis Controlled study Cannabis increased pain sensitivity
Show Pain Effects of moderate and high doses of marihuana on thermal pain: a sensory decision theory analysis. Clark WC, Janal MN, Zeidenberg P, Nahas GG. 1981 Cannabis Controlled study Cannabis increased perseption of pain
Show Pain Lack of effect of cannabidiol in sustained neuropathia. Lindstrom P, Lindblom U, Boreus L. 1987 Cannabidiol Controlled study no effect of CBD on pain
Show HIV/AIDS;Pain Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Ellis RJ, Toperoff W, Vaida F, van den Brande G, Gonzales J, Gouaux B, Bentley H, Atkinson JH. 2009 Cannabis Controlled study Significant pain relief with cannabis.
Show Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin. Dvorak M, Watkinson A, McGlone F, Rukwied R. 2003 Other cannabinoids Controlled study Peripheral administration of HU210 attenuates histamine-induced itch
Show Pain Cannabinoid agonists attenuate capsaicin-induced responses in human skin. Rukwied R, Watkinson A, McGlone F, Dvorak M. 2003 Other cannabinoids Controlled study A topically applied cannabinoid receptor agonist (HU210) reduced pain caused by capsaicin
Show Effect of Delta(9)-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans. Beaumont H, Jensen J, Carlsson A, Ruth M, Lehmann A, Boeckxstaens GE. 2009 Delta-9-THC Controlled study THC reduced acid reflux episodes in the first hour after a meal.
Show Multiple sclerosis Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study. Aragona M, Onesti E, Tomassini V, Conte A, Gupta S, Gilio F, Pantano P, Pozzilli C, Inghilleri M. 2009 Cannabis Controlled study Cannabis did not impair cognition
Show Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism. Trevaskis NL, Shackleford DM, Charman WN, Edwards GA, Gardin A, Appel-Dingemanse S, Kretz O, Galli B, Porter CJ. 2009 Other cannabinoids Controlled study Systemic bioavailability of the cannabinoid CRA13 increased by more than 4-fold if taken together with a fat-rich meal.
Show Multiple sclerosis Cannabinoid influence on cytokine profile in multiple sclerosis. Katona S, Kaminski E, Sanders H, Zajicek J. 2005 Cannabis;Delta-9-THC Controlled study There were no significant effects of cannabinoids on the cytokine profiles examined.
Show Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers. Martín-Santos R, Crippa JA, Batalla A, Bhattacharyya S, Atakan Z, Borgwardt S, Allen P, Seal M, Langohr K, Farré M, Zuardi AW, McGuire P. 2012 Delta-9-THC;Cannabidiol Controlled study CBD does not cause significant side effects
Show Pain A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction. Ostenfeld T, Price J, Albanese M, Bullman J, Guillard F, Meyer I, Leeson R, Costantin C, Ziviani L, Nocini PF, Milleri S. 2011 Other cannabinoids Controlled study No superior analgetic effect of the synthetic cannabinoid GW842166 over placebo.
Show Spasticity Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial. Weber M, Goldman B, Truniger S. 2010 Delta-9-THC Controlled study There were no effects on cramp intensity, number of cramps and fasciculation intensity.
Show Spasticity;Spinal cord injury A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury. Pooyania S, Ethans K, Szturm T, Casey A, Perry D. 2010 Nabilone Controlled study There was a significant decrease in spasticity by nabilone.
Show Appetite loss/weight loss;Cancer Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial. Brisbois TD, de Kock IH, Watanabe SM, Mirhosseini M, Lamoureux DC, Chasen M, Macdonald N, Baracos VE, Wismer WV. 2011 Delta-9-THC Controlled study THC improved taste and appetite
Show Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration. Karschner EL, Darwin WD, McMahon RP, Liu F, Wright S, Goodwin RS, Huestis MA. 2011 Cannabis;Delta-9-THC;Cannabidiol Controlled study Oral THC and the cannabis extract Sativex produced similar effects
Show Anxiety Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA. 2011 Cannabidiol Controlled study Cannabidiol significamtly reduced anxiety.
Show Separate and combined effects of the cannabinoid agonists nabilone and Δ(9)-THC in humans discriminating Δ(9)-THC. Lile JA, Kelly TH, Hays LR. 2011 Delta-9-THC;Nabilone Controlled study THC caused similar effects as nabilone
Show Nausea/vomiting;Cancer;Cancer chemotherapy Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. Duran M, Pérez E, Abanades S, Vidal X, Saura C, Majem M, Arriola E, Rabanal M, Pastor A, Farré M, Rams N, Laporte JR, Capellà D. 2010 Cannabis Controlled study Cannabis was superior to placebo in reducing nausea and vomiting in patients refractory to other medications
Show Pain Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study. Rintala DH, Fiess RN, Tan G, Holmes SA, Bruel BM. 2010 Delta-9-THC Controlled study No significant difference between THC and diphenhydramine.
Show Multiple sclerosis Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. Kavia RB, De Ridder D, Constantinescu CS, Stott CG, Fowler CJ. 2010 Cannabis Controlled study The cannabis extract had some effect on overactive bladder symptoms.
Show Anxiety Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL, Martin-Santos R, Simões MV, Bhattacharyya S, Fusar-Poli P, Atakan Z, Santos Filho A, Freitas-Ferrari MC, McGuire PK, Zuardi AW, Busatto GF, Hallak JE. 2011 Cannabidiol Controlled study CBD reduces anxiety in patients with generalized social anxiety disorder.
Show Appetite loss/weight loss;HIV/AIDS Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study. Bedi G, Foltin RW, Gunderson EW, Rabkin J, Hart CL, Comer SD, Vosburg SK, Haney M. 2010 Delta-9-THC Controlled study Tolerance developed to the appetite-increasing effects of THC.
Show Pain Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. Ware MA, Wang T, Shapiro S, Robinson A, Ducruet T, Huynh T, Gamsa A, Bennett GJ, Collet JP. 2010 Cannabis Controlled study Cannabis improved pain and sleep quality.
Show The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients. Klooker TK, Leliefeld KE, Van Den Wijngaard RM, Boeckxstaens GE. 2011 Delta-9-THC Controlled study THC did not modify visceral perception to rectal distension.
Show Cannabinoid effects on ventilation and breathlessness: A pilot study of efficacy and safety. Pickering EE, Semple SJ, Nazir MS, Murphy K, Snow TM, Cummin AR, Moosavi S, Guz A, Holdcroft A. 2011 Cannabis Controlled study With cannabis participants felt less breathless
Show Multiple sclerosis;Spasticity A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Novotna A, Mares J, Ratcliffe S, Novakova I, Vachova M, Zapletalova O, Gasperini C, Pozzilli C, Cefaro L, Comi G, Rossi P, Ambler Z, Stelmasiak Z, Erdmann A, Montalban X, Klimek A, Davies P; the Sativex Spasticity Study Group. 2011 Cannabis Controlled study The cannabis extract significantly reduced spasticity.
Show Cancer;Pain Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain. Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. 2010 Cannabis;Delta-9-THC Controlled study A cannabis extract containing THC and CBD was superior in reducing pain than placebo.
Show Dependency/withdrawal Safety of oral dronabinol during opioid withdrawal in humans Jicha CJ, Lofwall MR, Nuzzo PA, Babalonis S, Elayi SC, Walsh SL. 2015 Delta-9-THC Controlled study 40 mg of THC caused increased heart rate and anxiety, which made dose-reduction necessary
Show Pain Randomised Placebo Controlled Double Blind Clinical Trial of Cannabis Based Medicinal Product (Sativex) in Painful Diabetic Neuropathy: Depression is a Major Confounding Factor. Selvarajah D, Gandhi R, Emery CJ, Tesfaye S. 2010 Cannabis Controlled study No difference between cannabis extract and placebo.
Show Spasticity;Multiple sclerosis Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis. Centonze D, Mori F, Koch G, Buttari F, Codecà C, Rossi S, Cencioni MT, Bari M, Fiore S, Bernardi G, Battistini L, Maccarrone M. 2009 Cannabis Controlled study There was no effect of the cannabis extract on spasticity
Show Pain The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. Ware MA, Fitzcharles MA, Joseph L, Shir Y. 2010 Nabilone Controlled study Improvement of sleep by nabilone.
Show Multiple sclerosis;Pain Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosis. Conte A, Bettolo CM, Onesti E, Frasca V, Iacovelli E, Gilio F, Giacomelli E, Gabriele M, Aragona M, Tomassini V, Pantano P, Pozzilli C, Inghilleri M. 2009 Cannabis Controlled study The study provides objective neurophysiological evidence that cannabinoids modulate the nociceptive system.
Show Multiple sclerosis Randomised controlled trial of cannabis based medicine (CBM, Stativex®) to treat detrusor overactivity in multiple sclerosis. Kavia R, De Ridder D, Sarantis N, Constantinescu C, Fowler. 2000 Cannabis Controlled study There was no effect on daily incontinence, but the cannabis extract was superior to placebo for nocturia.
Show Pain An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee. Huggins JP, Smart TS, Langman S, Taylor L, Young T. 2012 Other cannabinoids Controlled study A FAAH inhibitor was not more effective than a placebo.
Show Diarrhoea;Gastrointestinal disorder Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome. Wong BS, Camilleri M, Busciglio I, Carlson P, Szarka LA, Burton D, Zinsmeister AR. 2011 Delta-9-THC Controlled study Dronabinol reduces fasting motility of the colon in IBS patients with diarrhoea
Show Traumatic brain injury Early Survival of Comatose Patients after Severe Traumatic Brain Injury with the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271: A Randomized, Double-Blind, Placebo-Controlled Phase II Trial. Firsching R, Piek J, Skalej M, Rohde V, Schmidt U, Striggow F; the KN38-7271 Study Group. 2012 Other cannabinoids Controlled study Survival rates within 1 month of the injury were significantly better.
Show Anxiety Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images. Ballard ME, Bedi G, de Wit H. 2012 Delta-9-THC Controlled study THC renders fearful faces less fearful
Show Cancer;Pain Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. Portenoy RK, Ganae-Motan ED, Allende S, Yanagihara R, Shaiova L, Weinstein S, McQuade R, Wright S, Fallon MT. 2012 Cannabis Controlled study Additional pain reduction following the two lower doses.
Show Anxiety;Posttraumatic stress disorder Cannabinoid facilitation of fear extinction memory recall in humans. Rabinak CA, Angstadt M, Sripada CS, Abelson JL, Liberzon I, Milad MR, Phan KL. 2012 Delta-9-THC Controlled study THC prevented the recovery of fear in this experiment of extinction learning.
Show Multiple sclerosis;Pain;Spasticity Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial. Zajicek JP, Hobart JC, Slade A, Barnes D, Mattison PG; on behalf of the MUSEC Research Group. 2012 Cannabis Controlled study Significant improvement by the cannabis extract Cannador of spasticity and pain.
Show Pain Lack of effect of central nervous system-active doses of nabilone on capsaicin-induced pain and hyperalgesia. Kalliomäki J, Philipp A, Baxendale J, Annas P, Karlsten R, Segerdahl M. 2012 Nabilone Controlled study The cannabinoid had no significant effect on acute experimental pain.
Show HIV/AIDS A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJ. 2011 Cannabis Controlled study Cannabis modulates the concentration of appetite hormones
Show Appetite loss/weight loss;HIV/AIDS A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJ 2012 Cannabis Controlled study Cannabis administration was associated with significant increases in plasma levels of ghrelin and leptin, and decreases in PYY, but did not significantly influence insulin levels
Show Multiple sclerosis;Spasticity Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial. Zajicek J, Ball S, Wright D, Vickery J, Nunn A, Miller D, Cano MG, McManus D, Mallik S, Hobart J; on behalf of the CUPID investigator group. 2013 Delta-9-THC Controlled study THC, which was given for 36 months, had no effect on progression compared to placebo
Show Cancer chemotherapy;Pain A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain. Lynch ME, Cesar-Rittenberg P, Hohmann AG. 2013 Cannabis Controlled study Five patients tended to respond to a treatment with cannabis
Show Anxiety;Posttraumatic stress disorder Cannabidiol enhances consolidation of explicit fear extinction in humans. Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ 2013 Cannabidiol Controlled study Cannabidiol enhances consolidation of fear extinction in humans.
Show Psychosis/schizophrenia A controlled family study of cannabis users with and without psychosis. Proal AC, Fleming J, Galvez-Buccollini JA, Delisi LE. 2013 Cannabis Controlled study Cannabis does not cause psychosis by itself
Show Pain The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial For Pain. Issa MA, Narang S, Jamison RN, Michna E, Edwards RR, Penetar DM, Wasan AD. 2013 Cannabis;Delta-9-THC Controlled study In pain patients, oral dronabinol has similar psychoactive effects to smoking cannabis.
Show Dependency/withdrawal Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial Allsop DJ, Copeland J, Lintzeris N, Dunlop AJ, Montebello M, Sadler C, Rivas GR, Holland RM, Muhleisen P, Norberg MM, Booth J, McGregor IS 2014 Cannabis Controlled study Sativex had no relevant long-term effect on cannabis dependence
Show Dependency/withdrawal Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial. Levin FR, Mariani JJ, Brooks DJ, Pavlicova M, Cheng W, Nunes EV 2011 Delta-9-THC Controlled study THC caused significant improvement in treatment retention and withdrawal symptoms.
Show Pain A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment Serpell M, Ratcliffe S, Hovorka J, Schofield M, Taylor L, Lauder H, Ehler E 2014 Cannabis Controlled study Significant improvements in pain, sleep quality and subjective evaluations of patients.
Show Multiple sclerosis;Pain A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S 2013 Cannabis Controlled study No significant difference between placebo and Sativex in Phase A; Phase B demonstrated an analgesic effect.
Show Gastrointestinal disorder;Inflammation;Pain Konikoff FM. Cannabis induces a clinical response in patients with Crohn's disease: a prospective placebo-controlled study Naftali T, Bar-Lev Schleider L, Dotan I, Lansky EP, Sklerovsky Benjaminov F, Konikoff FM 2013 Cannabis Controlled study Cannabis produced significant clinical benefits in 10 of 11 patients with active Crohn’s disease.
Show Pain Low-dose vaporized cannabis significantly improves neuropathic pain Wilsey B, Marcotte T, Deutsch R, Gouaux B, Sakai S, Donaghe H 2013 Cannabis Controlled study Cannabis reduced pain. No difference in efficacy between the two doses.
Show Parkinson's disease Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA 2014 Cannabidiol Controlled study Significant improvement in well-being. No effects on motor functioning or neuroprotection.
Show Multiple sclerosis;Spasticity A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis Collin C, Ehler E, Waberzinek G, Alsindi Z, Davies P, Powell K, Notcutt W, O'Leary C, Ratcliffe S, Nováková I, Zapletalova O, Piková J, Ambler Z 2010 Cannabis Controlled study Significant reduction in treatment-resistant spasticity.
Show Diarrhoea;Gastrointestinal disorder Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea Wong BS, Camilleri M, Eckert D, Carlson P, Ryks M, Burton D, Zinsmeister AR 2012 Delta-9-THC Controlled study THC had no significant effects on gut transit.
Show Pain Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH 2015 Cannabis Controlled study Inhaled cannabis demonstrated a dose dependent reduction in peripheral treatment-refractory neuropathic pain.
Show Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers. Tudge L, Williams C, Cowen PJ, McCabe C 2015 Other cannabinoids Controlled study The natural cannabinoid tetrahydrocannabivarin (THCV) altered the nerve response to pleasant and unpleasant stimuli in a way that it “suggests therapeutic activity in obesity.
Show Posttraumatic stress disorder The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. Jetly R, Heber A, Fraser G, Boisvert D. 2015 Nabilone Controlled study Nabilone reduced nightmares.
Show Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: A randomized controlled trial. Ahmed AI, van den Elsen GA, Colbers A, van der Marck MA, Burger DM, Feuth TB, Rikkert MG, Kramers C. 2014 Delta-9-THC Controlled study THC appeared to be safe and well tolerated by healthy older individuals.
Show Pain Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers. Cooper ZD, Comer SD, Haney M. 2013 Cannabis;Delta-9-THC Controlled study THC (dronabinol) and smoked cannabis (marijuana) caused similar effects on pain sensitivity and pain tolerance.
Show Appetite loss/weight loss;Cancer;Nausea/vomiting;Pain Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial Côté M, Trudel M, Wang C, Fortin A. 2015 Nabilone Controlled study Nabilone did not reduce pain and nausea in patients treated for head and neck cancer.
Show Pain Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability de Vries M, van Rijckevorsel DC, Vissers KC, Wilder-Smith OH, van Goor H(; Pain and Nociception Neuroscience Research Group 2015 Delta-9-THC Controlled study No effect of a single low dose of THC on abdominal pain resulting from chronic pancreatitis in clinical study.
Show Pain A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. Lynch ME, Cesar-Rittenberg P, Hohmann AG. 2014 Cannabis Controlled study Reduction in pain intensity
Show Pain The subjective psychoactive effects of oral dronabinol studied in a randomized, controlled crossover clinical trial for pain. Issa MA, Narang S, Jamison RN, Michna E, Edwards RR, Penetar DM, Wasan AD. 2014 Cannabis;Delta-9-THC Controlled study Oral THC had similar psychoactive effects to smoked marijuana
Show Alzheimer's disease Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial. van den Elsen GA, Ahmed AI, Verkes RJ, Kramers C, Feuth T, Rosenberg PB, van der Marck MA, Olde Rikkert MG. 2015 Delta-9-THC Controlled study No reduction in NPS by low-dose THC (3x1.5mg), though it is well-tolerated
Show Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users. Hindocha C, Freeman TP, Schafer G, Gardener C, Das RK, Morgan CJ, Curran HV. 2015 Cannabis;Delta-9-THC;Cannabidiol Controlled study Improvement of recognition of emotional facial affect by CBD and attenuation of the impairment induced by THC
Show The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. 2015 Delta-9-THC Controlled study Inhibition of some of the well-known effects of THC by THCV and potentiation of other effects
Show Pain Tetrahydrocannabinol Does not Reduce Pain in Patients With Chronic Abdominal Pain in a Phase 2 Placebo-controlled Study. de Vries M, van Rijckevorsel DC, Vissers KC, Wilder-Smith OH, van Goor H; Pain and Nociception Neuroscience Research Group. 0000 Delta-9-THC Controlled study No effect of THC on pain in patients with abdominal pain
Show Pain A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis. Wilsey BL, Deutsch R, Samara E, Marcotte TD, Barnes AJ, Huestis MA, Le D. 2016 Delta-9-THC Controlled study Moderate relationship between THC concentrations and reduction of pain
Show Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial. van den Elsen GA, Tobben L, Ahmed AI, Verkes RJ, Kramers C, Marijnissen RM, Olde Rikkert MG, van der Marck MA. 2016 Delta-9-THC Controlled study No differences in the number and type of adverse events were found, and no falls occurred after administration of THC.
Show Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD. 2016 Other cannabinoids Controlled study THCV significantly decreased fasting plasma glucose and improved the function of cells in the pancreas
Show Pain;Spinal cord injury An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease. Wilsey B, Marcotte TD, Deutsch R, Zhao H, Prasad H, Phan A. 2016 Cannabis Controlled study Inhaled cannabis reduces neuropathic pain in patients with spinal cord injury
Show Bipolar disorders Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood. Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. 2016 Cannabis Controlled study Cannabis showed beneficial effects in bipolar disorder
Show Multiple sclerosis The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. Marinelli L, Mori L, Canneva S, Colombano F, Currà A, Fattapposta F, Bandini F, Capello E, Abbruzzese G, Trompetto C. 2016 Cannabis Controlled study Cannabis reduces the stretch reflex in patients with multiple sclerosis
Show Pain Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial. Malik Z, Bayman L, Valestin J, Rizivi-Toner A, Hashmi S, Schey R. 2016 Delta-9-THC Controlled study THC reduced pain intensity and odynophagia (painful swallowing, in the mouth or oesophagus).
Show Epilepsy CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Tzadok M, Uliel-Siboni S, Linder I, Kramer U, Epstein O, Menascu S, Nissenkorn A, Yosef OB, Hyman E, Granot D, Dor M, Lerman-Sagie T, Ben-Zeev B. 2016 Cannabidiol Controlled study Improvement in behaviour and alertness, language, communication, motor skills and sleep
Show Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population. Rhyne DN, Anderson S, Gedde M, Borgelt LM. 2016 Other cannabinoids Controlled study Migraine headache frequency on average decreased from 10.4 to 4.6 headaches per month with the use of cannabis.
Show Attention-deficit/hyperactivity disorder Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P 2017 Other cannabinoids Controlled study Cannabis reduced symptoms of ADHD in a small clinical study
Show A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study Jadoon KA, Tan GD, O'Sullivan SE 2017 Cannabidiol Controlled study CBD reduces blood pressure in healthy people
Show Cancer;Pain Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. Fallon MT et al. 2017 Cannabidiol;Other cannabinoids Controlled study A cannabis extract did not reduce pain in advanced cancer patients, who did not respond to opioids
Show Evaluation of divided attention psychophysical task performance and effects on pupil sizes following smoked, vaporized and oral cannabis administration Newmeyer MN, Swortwood MJ, Taylor ME, Abulseoud OA, Woodward TH, Huestis MA 2017 Cannabis Controlled study Effects of inhaled and oral THC on pupil size and psychomotor performance
Show Attention-deficit/hyperactivity disorder Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial R.E. Cooper, E. Williams, S. Seegobin, C. Tye, J. Kuntsi, P. Asherson 2016 Delta-9-THC;Cannabidiol Controlled study Cannabis may be helpful in the treatment of ADHD
Show Multiple sclerosis;Spasticity Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis. van Amerongen G, Kanhai K, Baakman AC, Heuberger J, Klaassen E, Beumer TL, Strijers RL, Killestein J, van Gerven J, Cohen A, Groeneveld GJ 2017 Delta-9-THC Controlled study THC showed mixed results in the treatment of pain and spasticity in multiple sclerosis
Show Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome Cremon C et el. 2017 Controlled study A treatment with palmithoylethanolamide and polydatin improved pain in irritable bowel syndrome
Show Nausea/vomiting A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery Levin DN, Dulberg Z, Chan AW, Hare GM, Mazer CD, Hong A 2017 Nabilone Controlled study Nabilone was not effective in reducing postoperative nausea and vomiting
Show Epilepsy;Rare diseases Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S; Cannabidiol in Dravet Syndrome Study Group. 2017 Cannabidiol Controlled study Cannabidiol effective against epilepsy in Dravet syndrome
Show Older adults' marijuana use, injuries, and emergency department visits Choi NG, Marti CN, DiNitto DM, Choi BY 2017 Cannabis Controlled study Cannabis use may increase injury risk among older adults
Show Pain Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial. Wagenlehner FM, et al. 2017 Other cannabinoids Controlled study An inhibitor of FAAH did not influence pain in patients with chronic prostatitis
Show Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study Faig-Martí J, Martínez-Catassús A 2017 Other cannabinoids Controlled study Palmitoylethanolamide moderately effective in the treatment of carpal tunnel syndrome
Show Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial. Naftali T, et al. 2017 Cannabidiol Controlled study Very low doses of CBD were not effective in Crohn’s disease
Show Psychosis/schizophrenia The impact of current cannabis use on general cognitive function in people with psychotic illness Waterreus A, Badcock JC, Di Prinzio P, Martin-Iverson M, Morgan VA 2017 Cannabis Controlled study No difference in cognitive abilities between people with psychosis with and without cannabis use
Show Dependency/withdrawal Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal Hindocha C. et al. 2018 Cannabidiol Controlled study CBD may be helpful in tobacco dependency
Show Rare diseases Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial Thiele EA. et al. 2018 Cannabidiol Controlled study CBD is effective against seizures in Lennox-Gastaut syndrome
Show Rare diseases Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome Devinsky O. et al. 2018 Cannabidiol Controlled study The use of CBD in children has only minimal effects on other antiepileptic drugs
Show Appetite loss/weight loss;Cancer The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial Turcott JG, Del Rocío Guillen Núñez M, Flores-Estrada D, Oñate-Ocaña LF, Zatarain-Barrón ZL, Barrón F, Arrieta O 2018 Nabilone Controlled study Nabilone improved appetite in cancer patients in a controlled clinical study
Show A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis Irving PM et al. 2018 Cannabidiol Controlled study A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study
Show A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis Irving PM et al. 2018 Cannabidiol Controlled study A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study
Show Psychosis/schizophrenia The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial Boggs DL et al. 2018 Cannabidiol Controlled study CBD did not improve cognition in patients with schizophrenia
Show Pain The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain. Bradford D et al. 2017 Other cannabinoids Controlled study A FAAH inhibitor did not reduce neuropathic pain
Show HIV/AIDS HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients Rizzo MD et al. 2018 Cannabis Controlled study Cannabis may slow inflammation of the brain in patients with HIV and may maintain cognitive performance
Show Psychosis/schizophrenia Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial McGuire P et al. 2018 Cannabidiol Controlled study Cannabidiol may be helpful in schizophrenia according to clinical study
Show Sleep disorder Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea Carley DW et al. 2018 Other cannabinoids Controlled study THC may be effective in the treatment of sleep apnoea according to a clinical study
Show No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Linares IMP et al. 2018 Cannabidiol Controlled study CBD may be used against anxiety and depression without altering normal sleep
Show Dependency/withdrawal The effect of high-dose dronabinol (oral THC) maintenance on cannabis self-administration Schlienz NJ, Lee DC, Stitzer ML, Vandrey R 2018 Delta-9-THC Controlled study High doses of oral THC reduced intake of inhaled THC
Show Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O. et al. 2018 Cannabidiol Controlled study
Show Dependency/withdrawal The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers. Hindocha C, Freeman TP, Grabski M, Crudgington H, Davies AC, Stroud JB, Das RK, Lawn W, Morgan CJA, Curran HV. 2018 Cannabidiol Controlled study
Show Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Khalaj M. et al. 2018 Other cannabinoids Controlled study
Show Multiple sclerosis Sativex® as Add-on therapy Vs. further optimized first-line ANTispastics (SAVANT) in resistant multiple sclerosis spasticity: a double-blind, placebo-controlled randomised clinical trial. Markovà J, Essner U, Akmaz B, Marinelli M, Trompke C, Lentschat A, Silván CV 2018 Other cannabinoids Controlled study Long-term efficacy of a cannabis spray in the treatment of spasticity due to multiple sclerosis
Show Pain The relationship of endocannabinoidome lipid mediators with pain and psychological stress in women with fibromyalgia - a case control study Stensson N, Ghafouri N, Ernberg M, Mannerkorpi K, Kosek E, Gerdle B, Ghafouri B 2018 Other cannabinoids Controlled study Fibromyalgia is associated with increased blood levels of endocannabinoids
Show Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study Corrado A, Battle M, Wise SK, Lee FE, Guidot DM, DelGaudio JM, Molina SA, Levy JM 2018 Other cannabinoids Controlled study The number of CB2 receptors is increased in a certain respiratory disease
Show Alzheimer's disease Treating non-cognitive symptoms of people with dementia Science Daily 2018 Delta-9-THC Controlled study Nabilone improves agitation and other behavioural symptoms in patients with Alzheimer’s disease
Show Psychosis/schizophrenia Impact of substance use disorder on gray matter volume in schizophrenia. Quinn M, McHugo M, Armstrong K, Woodward N, Blackford J, Heckers S. 2018 Cannabis Controlled study Cannabis use does not influence gray matter of the brain in schizophrenia
Show Pain Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity. Weizman L, Dayan L, Brill S, Nahman-Averbuch H, Hendler T, Jacob G, Sharon H. 2018 Delta-9-THC Controlled study THC reduces neuropathic pain and this is associated with altered connections between two brain regions
Show Epilepsy Efficacy of cannabinoids in paediatric epilepsy Ali S, Scheffer IE, Sadleir LG. 2018 Cannabidiol Controlled study CBD is similar effective as established antiepileptic drugs
Show Vaporization as a smokeless cannabis delivery system: a pilot study. Abrams DI, Vizoso HP, Shade SB, Jay C, Kelly ME, Benowitz NL 2007 Cannabis Controlled study;Basic research Vaporization of cannabis is a safe and effective mode of delivery of THC
Show Pain Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy Narang S, Gibson D, Wasan AD, Ross EL, Michna E, Nedeljkovic SS, Jamison RN 2007 Delta-9-THC Controlled study;Open study THC had an additional effect on pain relief
Show Effect of cannabis and tobacco on emphysema in patients with spontaneous pneumothorax Ruppert AM et al. 2018 Cannabis Controlled study;Open study Cannabis use may accelerate the development of emphysema in tobacco smokers
Show Cancer chemotherapy; Nausea/vomiting An efficient new cannabinoid antiemetic in pediatric oncology. Abrahamov A, Abrahamov A, Mechoulam R 1995 Delta-9-THC Open study complete prevention of emesis
Show Dystonia; Parkinson's disease Open label evaluation of cannabidiol in dystonic movement disorders. Consroe P, Sandyk R, Snider SR 1986 Cannabidiol Open study 20-50% improvement of dystonia; deterioration of tremor and hypokinesia in 2 patients with Parkinson's disease
Show Appetite loss/weight loss;Cancer Dronabinol enhancement of appetite in cancer patients. Wadleigh R, Spaulding GM, Lumbersky B, Zimmer M, Shepard K, Plasse T 1990 Delta-9-THC Open study Patients continued to loose, but the weight loss decreased in all groups; appetite and mood increased
Show Appetite loss/weight loss;HIV/AIDS Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. Beal JE, Olson R, Lefkowitz L, Laubenstein L, Bellman P, Yangco B, Morales JO, Murphy R, Powderly W, Plasse TF, Mosdell KW, Shepard KV 1997 Delta-9-THC Open study tendency to stable weight for 7 months
Show Asthma Acute and subacute bronchial effects of oral cannabinoids. Gong H Jr, Tashkin DP, Simmons MS, Calvarese B, Shapiro BJ 1984 Delta-9-THC Open study acute bronchodilator activity of delta 9-THC; no effect of cannabidiol; daily use of delta 9-THC not associated with tolerance
Show Appetite loss/weight loss;HIV/AIDS Dronabinol effects on weight in patients with HIV infection. Gorter R, Seefried M, Volberding P 1992 Delta-9-THC Open study weight gain
Show Glaucoma Marihuana smoking and intraocular pressure. Hepler RS, Frank IR 1971 Cannabis Open study 9 of 11 had drop in intraocular pressure of 16-45%
Show Appetite loss/weight loss;Cancer A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. Nelson K, Walsh D, Deeter P, Sheehan F 1994 Delta-9-THC Open study increase of appetite in 13 patients
Show Appetite loss/weight loss;Alzheimer's disease Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review Patel S, Shua-Haim JR, Pass M 2003 Delta-9-THC Open study Weight gain in all, reduction of agitation in 65%.
Show Multiple sclerosis An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis. Brady CM, DasGupta R, Dalton C, Wiseman OJ, Berkley KJ, Fowler CJ. 2004 Cannabis Open study Urinary urgency, the number and volume of incontinence episodes, frequency and nocturia all decreased.
Show Glaucoma Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon? Flom MC, Adams AJ, Jones RT 1975 Delta-9-THC Open study IOP reduction in 7 of 15
Show Appetite loss/weight loss;HIV/AIDS Recent clinical experience with dronabinol. Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG 1991 Delta-9-THC Open study Significant weight gain
Show Alzheimer's disease Open-label study of dronabinol in the treatment of refractory agitation in Alzheimer’s disease: a pilot study Ross JS, Shua-Haim JR 2003 Delta-9-THC Open study Significant reduction of agitation
Show Pain [The therapeutic use of delta-9-tetrahydrocannabinol (dronabinol) in refractory neuropathic pain] [Article in French]. Clermont-Gnamien S, Atlani S, Attal N, Le Mercier F, Guirimand F, Brasseur L. 2002 Delta-9-THC Open study No signficant effect of THC on pain
Show HIV/AIDS;Pain The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods. Abrams DI, Jay Ch, Petersen K, Shade S, Vizoso H, Reda H, Benowitz N, Rowbotham M. 2003 Cannabis Open study 10 of the 16 participants experienced a greater than 30% reduction in their pain
Show Multiple sclerosis Acute and chronic effects of cannabis based medicinal extract on refractory lower urinary tract dysfunction in patients with advanced multiple sclerosis – early results Brady CM, DasGupta R, Wiseman OJ, Berkley KJ, Fowler CJ 2001 Cannabis Open study Mean maximum cystometric capacity increased
Show Spasticity;Spinal cord injury Treatment of spasticity in spinal cord injury with dronabinol, a tetrahydrocannabinol derivative. Kogel RW, Johnson PB, Chintam R, Robinson CJ, Nemchausky BA. 1995 Delta-9-THC Open study Spasticity was markedly improved in 2 o 5 patients
Show Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease. Neff GW, O'Brien CB, Reddy KR, Bergasa NV, Regev A, Molina E, Amaro R, Rodriguez MJ, Chase V, Jeffers L, Schiff E. 2002 Delta-9-THC Open study THC signficantly reduced intractable cholestatic related pruritus
Show Nausea/vomiting;Cancer;Cancer chemotherapy A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues. Cunningham D, Bradley CJ, Forrest GJ, Hutcheon AW, Adams L, Sneddon M, Harding M, Kerr DJ, Soukop M, Kaye SB. 1988 Nabilone Open study Metoclopramide/dexamethasone superior to nabilone/prochlorperazine
Show Parkinson's disease Marijuana for parkinsonian tremor. Frankel JP, Hughes A, Lees AJ, Stern GM. 1990 Cannabis Open study No improvement of tremor
Show Pain Are oral cannabinoids safe and effective in refractory neuropathic pain? Attal N, Brasseur L, Guirimand D, Clermond-Gnamien S, Atlami S, Bouhassira D 2004 Delta-9-THC Open study No significant decraese of pain in 7 patients, more than 60% decrease in one patient
Show Appetite loss/weight loss;Cancer Dronabinol enhancement of appetite in cancer patients. Wadleigh R, Spaulding GM, Lumbersky B, Zimmer M, Shepard K, Plasse T. 1990 Delta-9-THC Open study Dronabinol stimulated mood and appetite
Show Nausea/vomiting;Cancer;Cancer chemotherapy Inhalation marijuana as an antiemetic for cancer chemotherapy. Vinciguerra V, Moore T, Brennan E. 1988 Cannabis Open study Marijuana effective as antiemetic agent
Show Multiple sclerosis;Pain Oromucosal ∆9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial. Rog DJ, Nurmikko TJ, Young CA. 2007 Cannabis Open study No development of tolerance within a period of two years of treatment
Show Nausea/vomiting;Appetite loss/weight loss Evaluation of oral cannabinoid-containing medications for the management of interferon and ribavirin-induced anorexia, nausea and weight loss in patients treated for chronic hepatitis C virus. Costiniuk CT, Mills E, Cooper CL 2008 Delta-9-THC;Nabilone Open study Improvement of appetite and reduction of nausea and vomiting by nabilone and dronabinol (THC)
Show Spasticity;Spinal cord injury The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury. Hagenbach U, Luz S, Ghafoor N, Berger JM, Grotenhermen F, Brenneisen R, Mader M. 2006 Delta-9-THC Open study Significant improvement of spasticity with THC
Show Epilepsy Treatment with CBD in oily solution of drug-resistant paediatric epilepsies. Pelliccia A, Grassi G, Romano A, Crocchialo P 2005 Cannabidiol Open study Improvement of epilepsy without side effects
Show Appetite loss/weight loss;Cancer;Pain Adjunctive nabilone in cancer pain and symptom management: a prospective observational study using propensity scoring. Maida V, Ennis M, Irani S, Corbo M, Dolzhykov M. 2008 Nabilone Open study Significant improvement of pain
Show Nausea/vomiting;Appetite loss/weight loss;Cancer;Pain;Depression;Anxiety The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients Maida V. 2006 Nabilone Open study Nabilone treatment improved pain, nausea, appetite and several other symptoms
Show Nausea/vomiting;Appetite loss/weight loss;Cancer;Cancer chemotherapy [Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.] [Article in German] Zutt M, Hanssle H, Emmert S, Neumann C, Kretschmer L. 2006 Delta-9-THC Open study A significant increase in appetite and decrease in nausea in most patients.
Show Cannabidiol monotherapy for treatment-resistant schizophrenia Zuardi AW, Hallak JE, Dursun SM, Morais SL, Faria Sanches R, Musty RE, Crippa JA. 2006 Cannabidiol Open study CBD monotherapy was not effective in treatment-resistant schizophrenia
Show Alzheimer's disease Delta-9-tetrahydrocannabinol for night-time agitation in severe dementia Walther S, Mahlberg R, Eichmann U, Kunz D 2006 Delta-9-THC Open study Reduction in night-time agitation in actigraphy and in the neuropsychiatric inventory NPI
Show Appetite loss/weight loss Anorexia of aging in long term care: is dronabinol an effective appetite stimulant? - a pilot study. Wilson MM, Philpot C, Morley JE 2007 Delta-9-THC Open study A trend towards weight gain
Show Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS THC improves appetite and reverses weight loss in AIDS patients Dejesus E, Rodwick BM, Bowers D, Cohen CJ, Pearce D 2007 Delta-9-THC Open study THC improved appetite and weight and reduced nausea
Show Cancer A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. Guzman M, Duarte MJ, Blazquez C, Ravina J, Rosa MC, Galve-Roperh I, Sanchez C, Velasco G, Gonzalez-Feria L. 2006 Delta-9-THC Open study THC was well tolerated in this pilot study of intrakranial cannabinoid administration
Show Pain Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief. Schley M, Legler A, Skopp G, Schmelz M, Konrad C, Rukwied R. 2006 Delta-9-THC Open study Five of the nine patients withdrew from the study due to side effects. Four patients experienced significant pain relief
Show [Topical cannabinoid agonists : An effective new possibility for treating chronic pruritus.] [Article in German] Stander S, Reinhardt HW, Luger TA. 2006 Other cannabinoids Open study Topical application of a cream with N-palmitoyl ethanolamine had a good antipruritic effect in most patients.
Show Glaucoma Dronabinol and retinal hemodynamics in humans. Plange N, Arend KO, Kaup M, Doehmen B, Adams H, Hendricks S, Cordes A, Huth J, Sponsel WE, Remky A. 2007 Delta-9-THC Open study THC reduced intraoculat pressure and improved blood circulation in the retina.
Show Multiple sclerosis;Pain Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors. Hamann W, di Vadi PP. 1999 Nabilone Open study Relieve of pain
Show Nausea/vomiting;HIV/AIDS Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea. de Jong BC, Prentiss D, McFarland W, Machekano R, Israelski DM. 2005 Cannabis Open study Cannabis improved adherence to antiretroviral therapy in HIV/AIDS
Show Appetite loss/weight loss Dronabinol - eine mögliche neue Therapieoption bei COPD-Patienten mit pulmonaler Kachexie [Dronabinol, a possible new therapeutic option in patients with COPD and pulmonal cachexia] Bergmann K-C 2005 Delta-9-THC Open study On average 1,5 kg of weight gain and increase of walking distance
Show Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study. Szepietowski JC, Szepietowski T, Reich A. 2005 Other cannabinoids Open study Improvement of pruritus with the cream
Show Multiple sclerosis;Dystonia Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol. Deutsch SI, Rosse RB, Connor JM, Burket JA, Murphy ME, Fox FJ. 2008 Delta-9-THC Open study Significant improvement of symptoms
Show Pain Experience with the synthetic cannabinoid nabilone in chronic noncancer pain. Berlach DM, Shir Y, Ware MA. 2006 Nabilone Open study 9 patients reported reduced pain intensity
Show Nausea/vomiting;Cancer An initial evaluation of Nabilone in the control of radiotherapy-induced nausea and vomiting. Priestman TJ, Priestman SG. 1984 Nabilone Open study Patients who did not respond to metaclopramide responded to nabilone.
Show Nausea/vomiting Prevention of nausea and vomiting following breast surgery. Layeeque R, Siegel E, Kass R, Henry-Tillman RS, Colvert M, Mancino A, Klimberg VS. 2006 Delta-9-THC Open study Postoperative nausea and vomiting was reduced by prophylactic administration of dronabinol and prochlorperazine
Show Nausea/vomiting Cannabis use improves retention and virological outcomes in patients treated for hepatitis C. Sylvestre DL, Clements BJ, Malibu Y. 2006 Cannabis Open study Participants who used cannabis maintained adherence to treatment more offen
Show Spasticity;Multiple sclerosis;Pain Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis. Wade DT, Makela PM, House H, Bateman C, Robson P. 2006 Cannabis Open study Long-term use of cannabis maintains its therapeutic effects
Show Dependency/withdrawal Concurrent cannabis use during treatment for comorbid ADHD and cocaine dependence: effects on outcome. Aharonovich E, Garawi F, Bisaga A, Brooks D, Raby WN, Rubin E, Nunes EV, Levin FR. 2006 Cannabis Open study Moderate cannabis use had a positive effect of retention rates and abstinence from cocaine
Show Cancer;Cancer chemotherapy Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel. Engels FK, de Jong FA, Sparreboom A, Mathot RA, Loos WJ, Kitzen JJ, de Bruijn P, Verweij J, Mathijssen RH. 2007 Cannabis Open study Cannabis did not influence the pharmacokinetics of the two anti-cancer drugs
Show Multiple sclerosis Cannabis; adverse effects from an oromucosal spray. Scully C. 2007 Cannabis Open study The spray caused reversible damage to the mucosa
Show Dependency/withdrawal Therapeutic use of cannabis by crack addicts in Brazil. Labigalini E Jr, Rodrigues LR, Da Silveira DX. 1999 Cannabis Open study Cannabis use helped patients to quit crack use by reducing the craving symptoms
Show Nausea/vomiting;Cancer;Cancer chemotherapy Effects of smoked cannabis and oral delta-9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. Musty RE, Rossi R. 2001 Cannabis;Delta-9-THC Open study Cannabis caused symptom relief in 70-100%, dronabinol caused symptom relief in 76-88%
Show Dependency/withdrawal Therapeutic use of cannabis by crack addicts in Brazil. Labigalini E, Jr., Rodrigues LR, Da Silveira DX. 1999 Cannabis Open study Cannabis reduced craving and helped patients to quit cocaine
Show Dependency/withdrawal Crack heads and roots daughters: The therapeutic use of cannabis in Jamaica. Dreher M. 2002 Cannabis Open study Cannabis was the most effective and readily available therapy to quit cocaine use
Show Cancer Nabilone for the treatment of paraneoplastic night sweats: a report of four cases. Maida V. 2008 Nabilone Open study Significant improvement of night sweats within 2 days
Show Pain A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. Toth C, Au S. 2008 Cannabis;Nabilone Open study Similar treatment effects and side effects of cannabinoids compared to other medications
Show Pain Open-label, add-on study of tetrahydrocannabinol for chronic nonmalignant pain. Haroutiunian S, Rosen G, Shouval R, Davidson E. 2008 Delta-9-THC Open study 5 patients reported adequate response to the treatment.
Show Obsessive compulsive disorder Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study. Grant JE, Odlaug BL, Chamberlain SR, Kim SW. 2011 Delta-9-THC Open study Statistically significant reduction in symptom severity.
Show Cancer Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women. D'Souza G, Palefsky JM, Zhong Y, Minkoff H, Massad LS, Anastos K, Levine AM, Moxley M, Xue XN, Burk RD, Strickler HD. 2010 Cannabis Open study Cannabis use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women.
Show Pain Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis. Gatti A, Lazzari M, Gianfelice V, Di Paolo A, Sabato E, Sabato AF. 2012 Other cannabinoids Open study Significant pain relief with palmitoylethanolamide (PEA)
Show Nausea/vomiting Motion sickness, stress and the endocannabinoid system. Choukèr A, Kaufmann I, Kreth S, Hauer D, Feuerecker M, Thieme D, Vogeser M, Thiel M, Schelling G. 2010 Open study Volunteers who developed acute motion sickness (n = 7) showed lower endocannabinoid levels during parabolic flights.
Show Appetite loss/weight loss Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. Morgan CJ, Freeman TP, Schafer GL, Curran HV. 2010 Cannabis Open study Effects depended on the ratio of CBD and THC with high CBD reducing appetite enhancing effects of THC.
Show Pain An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy. Bestard JA, Toth CC. 2010 Nabilone Open study The benefits of nabilone are similar as gabapentin
Show Pain Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life. Fiz J, Durán M, Capellà D, Carbonell J, Farré M. 2011 Cannabis Open study The use of cannabis was associated with reduction of some fibromyalgia symptoms.
Show Dependency/withdrawal Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence. Raby WN, Carpenter KM, Rothenberg J, Brooks AC, Jiang H, Sullivan M, Bisaga A, Comer S, Nunes EV 2009 Cannabis Open study Better adherence to natrexone therapy with intermittend cannabis use
Show Synthetic delta-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia. Schwarcz G, Karajgi B, McCarthy R. 2009 Cannabis Open study Improvement in 4 of 6 participants, of whom 3 showed a significant improvement.
Show Dependency/withdrawal White matter integrity in adolescents with histories of marijuana use and binge drinking. Jacobus J, McQueeny T, Bava S, Schweinsburg BC, Frank LR, Yang TT, Tapert SF. 2009 Cannabis Open study Brain damage was less in alcohol users who used also cannabis than in alcohol only users.
Show Pain Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State. Aggarwal SK, Carter GT, Sullivan MD, ZumBrunnen C, Morrill R, Mayer JD. 2009 Cannabis Open study 88 % suffer from more than one pain syndrome
Show Pain Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia. Phan NQ, Siepmann D, Gralow I, Ständer S. 2010 Other cannabinoids Open study Five of eight patients experienced a good pain relief
Show Posttraumatic stress disorder Medical cannabis use in post-traumatic stress disorder: a naturalistic observational study. Reznik I. 2011 Cannabis Open study In most cases a significant improvement in quality of life and pain, with some positive changes in severity of posttraumatic stress disorder was observed.
Show Diarrhoea;Gastrointestinal disorder;Inflammation Treatment of Crohn's disease with cannabis: an observational study. Naftali T, Lev LB, Yablekovitz D, Half E, Konikoff FM. 2011 Cannabis Open study Of the 30 patients 21 improved significantly
Show Inflammation Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study. Lahat A, Lang A, Ben-Horin S. 2011 Cannabis Open study Significant improvement of several symptoms.
Show Pain Cannabinoid-opioid interaction in chronic pain Abrams DI, Couey P, Shade SB, Kelly ME, Benowitz NL 2011 Cannabis Open study Pain was significantly decreased
Show Gastrointestinal disorder;Inflammation Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study Lahat A, Lang A, Ben-Horin S 2012 Cannabis Open study Improvement in general health perception, social functioning, ability to work, physical pain and depression; weight gain; average rise in BMI; average Harvey-Bradshaw index was reduced
Show Dependency/withdrawal Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment. Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ. 2013 Cannabis Open study Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization
Show Pain The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study Eisenberg E, Ogintz M, Almog S 2014 Cannabis Open study A significant reduction in pain intensity was achieved after cannabis inhalation with a vaporizer.
Show Cancer;Pain An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT 2013 Cannabis Open study The cannabis extract Sativex was generally well tolerated, with no evidence of a loss of effect for pain relief.
Show Epilepsy Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy Press CA, Knupp KG, Chapman KE 2015 Cannabis Open study About one third of children suffering from different forms of epilepsy experienced a more than 50 % reduction in seizures by the use of oral cannabis extracts.
Show HIV/AIDS High-intensity cannabis use associated with lower plasma human immunodeficiency virus-1 RNA viral load among recently infected people who use injection drugs. Milloy MJ, Marshall B, Kerr T, Richardson L, Hogg R, Guillemi S, Montaner JS, Wood E. 2015 Cannabis Open study At least daily cannabis use was associated with significant lower plasma HIV viral loads.
Show Endocannabinoids control platelet activation and limit aggregate formation under flow. De Angelis V, Koekman AC, Weeterings C, Roest M, de Groot PG, Herczenik E, Maas C. 2014 Other cannabinoids Open study Activation of cannabinoid receptors by cannabis use reduces platelet activation and blood clotting.
Show Traumatic brain injury Effect of marijuana use on outcomes in traumatic brain injury. Nguyen BM, Kim D, Bricker S, Bongard F, Neville A, Putnam B, Smith J, Plurad D. 2014 Cannabis Open study A positive THC screen is associated with decreased mortality in adult patients sustaining TBI [traumatic brain injury].
Show Pain;Posttraumatic stress disorder;Sleep disorder Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation. Cameron C, Watson D, Robinson J. 2014 Nabilone Open study Nabilone caused significant improvements in insomnia, nightmares, chronic pain and other symptoms in patients suffering from posttraumatic stress disorder (PTSD).
Show Multiple sclerosis Long-term effectiveness and safety of nabiximols (tetrahydrocannabinol/cannabidiol oromucosal spray) in clinical practice. Flachenecker P, Henze T, Zettl UK. 2014 Cannabis Open study Researchers found that “real-life data confirm the long-term effectiveness and tolerability of nabiximols [Sativex] for the treatment of resistant MSS [multiple sclerosis spasticity].
Show Cancer Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience. Waissengrin B, Urban D, Leshem Y, Garty M, Wolf I. 2015 Cannabis Open study Cannabis use “is perceived as highly effective” by some patients with advanced cancer.
Show Posttraumatic stress disorder Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder. Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A. 2014 Delta-9-THC Open study THC caused significant improvements in post-traumatic stress disorder (PTSD).
Show Parkinson's disease Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study. Lotan I, Treves TA, Roditi Y, Djaldetti R. 2014 Cannabis Open study Analysis of specific motor symptoms revealed significant, also sleep and pain improvement after treatment with cannabis.
Show Multiple sclerosis Nabiximols (THC/CBD oromucosal spray, Sativex®) in clinical practice--results of a multicenter, non-interventional study (MOVE 2) in patients with multiple sclerosis spasticity. Flachenecker P, Henze T, Zettl UK. 2014 Cannabis Open study The cannabis extract Sativex provided relief in 74.6% of participants.
Show Sleep disorder Impact of Dronabinol on Quantitative Electroencephalogram (qEEG) Measures of Sleep in Obstructive Sleep Apnea Syndrome. Farabi SS, Prasad B, Quinn L, Carley DW. 2014 Delta-9-THC Open study THC treatment yielded a shift in EEG (electroencephalogram) power toward delta and theta frequencies and a strengthening of normal rhythms in the sleep.
Show Multiple sclerosis;Spasticity Clinical experience with THC:CBD oromucosal spray in patients with multiple sclerosis-related spasticity. Koehler J, Feneberg W, Meier M, Pöllmann W. 2014 Cannabis Open study The mean spasticity decreased by 57%.
Show Cancer;Nausea/vomiting Dronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis. Hernandez SL, Sheyner I, Stover KT, Stewart JT. 2015 Delta-9-THC Open study THC may be very effective in the treatment of nausea and vomiting in end-stage cancer.
Show Multiple sclerosis;Spasticity Clinical experiences with cannabinoids in spasticity management in multiple sclerosis. Lorente Fernández L, Monte Boquet E, Pérez-Miralles F, Gil Gómez I, Escutia Roig M, Boscá Blasco I, Poveda Andrés JL, Casanova-Estruch B. 2014 Cannabis Open study The cannabis extract was effective in 80% of patients.
Show Sleep disorder Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers. Gorelick DA, Goodwin RS, Schwilke E, Schroeder JR, Schwope DM, Kelly DL, Ortemann-Renon C, Bonnet D, Huestis MA. 2013 Delta-9-THC Open study Higher THC concentrations were significantly associated with less difficulty falling asleep and more daytime sleep the following day.
Show Cancer The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care. Bar-Sela G, Vorobeichik M, Drawsheh S, Omer A, Goldberg V, Muller E. 2013 Cannabis Open study In an open clinical study with cancer patients all symptoms improved significantly.
Show HIV/AIDS Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis. Brunet L, Moodie EE, Rollet K, Cooper C, Walmsley S, Potter M, Klein MB; Canadian Co-infection Cohort Investigators. 2013 Cannabis Open study The use of cannabis did not accelerate progression to significant liver fibrosis.
Show Dependency/withdrawal Impact of cannabis use during stabilization on methadone maintenance treatment. Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ. 2013 Cannabis Open study Symptoms of opiate withdrawal decrease in patients undergoing methadone maintenance treatment, who use cannabis.
Show Alzheimer's disease Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms. Woodward MR, Harper DG, Stolyar A, Forester BP, Ellison JM. 2014 Delta-9-THC Open study A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite.
Show Dependency/withdrawal Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse. Haney M, Cooper ZD, Bedi G, Vosburg SK, Comer SD, Foltin RW. 2013 Nabilone Open study The use of nabilone reduced withdrawal symptoms.
Show Multiple sclerosis;Spasticity A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany. Flachenecker P. 2013 Cannabis Open study The cannabis extract sativex is effective in a large number of patients and well-tolerated in the long-term.
Show Multiple sclerosis;Spasticity Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain. García-Merino A. 2013 Cannabis Open study Sativex appears to be a well-tolerated and useful add-on therapy in patients with spasticity due to multiple sclerosis.
Show Spasticity Proof of concept trial of dronabinol in obstructive sleep apnea. Prasad B, Radulovacki MG, Carley DW. 2013 Delta-9-THC Open study THC significantly improved this condition.
Show Dependency/withdrawal The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. Vandrey R, Stitzer ML, Mintzer MZ, Huestis MA, Murray JA, Lee D. 2013 Delta-9-THC Open study THC dose-dependently attenuated cannabis withdrawal.
Show Pain;Parkinson's disease Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease. Shohet A, Khlebtovsky A, Roizen N, Roditi Y, Djaldetti R. 2016 Cannabis Open study Cannabis use improved pain and movement
Show Epilepsy Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. Hess EJ, Moody KA, Geffrey AL, Pollack SF, Skirvin LA, Bruno PL, Paolini JL, Thiele EA. 2016 Cannabidiol Open study cannabidiol (CBD) was shown to be effective in the treatment of epilepsy due to Tuberous sclerosis complex
Show Parkinson's disease Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease. Shohet A, Khlebtovsky A, Roizen N, Roditi Y, Djaldetti R. 2016 Cannabis Open study Cannabis improves pain and movement in patients with Parkinson’s disease
Show Pain The Effect of Medicinal Cannabis on Pain and Quality of Life Outcomes in Chronic Pain: A Prospective Open-label Study. Haroutounian S, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E. 0000 Cannabis Open study Cannabis reduced pain and opioid use
Show Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage. Di Napoli M, Zha AM, Godoy DA, Masotti L, Schreuder FH, Popa-Wagner A, Behrouz R; MNEMONICH Registry. 2016 Cannabis Open study Cannabinoids-positive patients had lower median disease scores on admission
Show Multiple sclerosis Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis. Russo M, Naro A, Leo A, Sessa E, D'Aleo G, Bramanti P, Calabrò RS. 2016 Other cannabinoids Open study Cannabis reduced neuropathic pain
Show Alzheimer's disease Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study. Shelef A, Barak Y, Berger U, Paleacu D, Tadger S, Plopsky I, Baruch Y. 2016 Cannabis Open study Following aspects significantly decreased: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress
Show Epilepsy Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR. 2015 Cannabidiol Open study Cannabidiol reduces seizure frequency in epilepsy of children and young adults
Show Pain Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients Fanelli G et al. 2017 Cannabis;Other cannabinoids Open study Cannabis may be effective in the treatment of chronic pain according to a large case series from Italy
Show Multiple sclerosis Cannabis and cognitive functioning in multiple sclerosis: The role of gender Patel VP, Feinstein A 2017 Cannabis Open study Cannabis use may have a negative effect on cognition in male patients with multiple sclerosis
Show Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke: A Population-Based Cohort Study of 45 000 Swedish Men Falkstedt D, Wolff V, Allebeck P, Hemmingsson T, Danielsson AK 2017 Cannabis Open study Cannabis use does not increase the risk of stroke in young people, while tobacco does
Show Pain Cannabinoids as effective as pharmaceutical treatments for migraine attacks Gary Scattergood 2017 Other cannabinoids Open study Cannabis effective in migraine and cluster headache in a clinical study
Show Inflammation Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis Annunziata P, Cioni C, Mugnaini C, Corelli F 2017 Open study Activation of the CB2 receptor counteracts inflammation of nerve cells
Show Moderate and vigorous physical activity patterns among marijuana users: Results from the 2007-2014 National Health and Nutrition Examination Surveys Vidot DC, Bispo JB, Hlaing WM, Prado G, Messiah SE 2017 Cannabis Open study Cannabis use was associated with reduced recreational physical activity
Show How does marijuana affect outcomes after trauma in ICU patients? A propensity-matched analysis Singer M, Azim A, O'Keeffe T, Khan M, Jain A, Kulvatunyou N, Gries L, Jehan F, Tang A, Joseph B 2017 Cannabis Open study Cannabis use may decrease mortality in trauma patients
Show Epilepsy Interactions between cannabidiol and commonly used antiepileptic drugs Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP; UAB CBD Program 2017 Cannabidiol Open study : CBD interacts with other anti-epileptic drugs
Show HIV/AIDS Confirmed marijuana use and lymphocyte count in black people living with HIV Keen L 2nd, Abbate A, Blanden G, Priddie C, Moeller FG, Rathore M 2017 Cannabis Open study Cannabis has no negative effect on the immune system in patients with HIV
Show Spinal cord injury Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience Grao-Castellote C, Torralba-Collados F, Gonzalez LM, Giner-Pascual M 2017 Other cannabinoids Open study Cannabis may be helpful in patients with spinal cord injuries according to an observational study
Show Appetite loss/weight loss Association Between Use of Cannabis in Adolescence and Weight Change into Midlife Jin LZ, Rangan A, Mehlsen J, Andersen LB, Larsen SC4, Heitmann BL 2017 Cannabis Open study Cannabis use during adolescence not associated with weight in midlife
Show Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers Oh DA, Parikh N, Khurana V, Cognata Smith C, Vetticaden S 2017 Other cannabinoids Open study Maximum blood concentrations after oral intake of THC were reached faster in a fasted state than in if taken together with a meal
Show Smoked marijuana attenuates performance and mood disruptions during simulated night shift work Keith DR, Gunderson EW, Haney M, Foltin RW, Hart CL 2017 Cannabis Open study The use of cannabis improves performance during simulated night shift work
Show Psychosis/schizophrenia Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators Bourque J, Afzali MH, O'Leary-Barrett M, Conrod P 2017 Cannabis Open study Cannabis use in adolescents was associated with psychotic-like experiences
Show Psychosis/schizophrenia Effect of continued cannabis use on medication adherence in the first two years following onset of psychosis Schoeler T, Petros N, Di Forti M, Klamerus E, Foglia E, Murray R, Bhattacharyya S 2017 Cannabis Open study Heavy cannabis use may reduce adherence to medication in patients with psychosis
Show Posttraumatic stress disorder Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders Ruglass LM, et al. 2017 Cannabis Open study Cannabis use had no relevant influence on outcome of behavioural therapies for co-occurring PTSD and substance use disorders
Show Inflammation Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids Utomo WK, et al. 2017 Open study Cannabis use alters immune cells in a way, which supports beneficial effects in inflammatory diseases and cancer
Show Psychosis/schizophrenia Association between alcohol, cannabis, and other illicit substance abuse and risk of developing schizophrenia: a nationwide population based register study Nielsen SM, Toftdahl NG, Nordentoft M, Hjorthøj C 2017 Cannabis Open study Cannabis and alcohol use were associated with increased risk of schizophrenia
Show Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Reis JP, et al. 2017 Cannabis Open study Cannabis use not associated with higher risk of cardiovascular diseases
Show Depression Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana Feingold D, Brill S, Goor-Aryeh I, Delayahu Y, Lev-Ran S 2017 Cannabis Open study Depression is higher in pain patients receiving opioids compared to those receiving cannabis
Show HIV/AIDS Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men 2017 Cannabis Open study Cannabis use may increase the risk for heart attacks in HIV positives
Show Depression Cannabis use and the course and outcome of major depressive disorder: A population based longitudinal study. Feingold D, Rehm J, Lev-Ran S 2017 Cannabis Open study No association between cannabis use and depression
Show Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study Androvicova R, et al. 2017 Cannabis Open study Cannabis increases the reaction to erotic stimuli
Show Long lasting effects of chronic heavy cannabis abuse Nestoros JN, Vakonaki E, Tzatzarakis MN, Alegakis A, Skondras MD, Tsatsakis AM 2017 Cannabis Open study Very heavy cannabis use may have long-lasting effects on the brain
Show Medical Marijuana Laws May Be Associated With A Decline In The Number Of Prescriptions For Medicaid Enrollees Bradford AC, Bradford WD 2017 Cannabis Open study The medical use of cannabis may reduce medical costs of Medicaid in the USA by about one billion dollars
Show Is Cannabis Use Associated with Various Indices of Motivation Among Adolescents? Pacheco-Colón I, Coxe S, Musser ED, Duperrouzel JC, Ross JM, Gonzalez R 2017 Cannabis Open study
Show Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis Karoly HC, Bidwell LC, Mueller RL, Hutchison KE 2018 Cannabis Open study Cannabinoid compounds may serve to mitigate inflammation associated with alcohol use
Show Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease. Adejumo AC, Ajayi TO, Adegbala OM, Adejumo KL, Alliu S, Akinjero AM, Onyeakusi NE, Ojelabi O, Bukong TN 2018 Cannabis Open study Cannabis use may be associated with a reduced incidence of liver disease in alcoholics
Show HIV/AIDS;Pain Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain Sohler NL, Starrels JL, Khalid L, Bachhuber MA, Arnsten JH, Nahvi S, Jost J, Cunningham CO 2018 Cannabis Open study Medical cannabis legislation might reduce the need for opioid analgesics for pain management
Show A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers Kiertscher SM, Gangalum PR, Ibrahim G, Tashkin DP, Roth MD 2018 Cannabis Open study
Show Marijuana Use and Renal Function Among US Adults Lu C, Papatheodorou SI, Danziger J, Mittleman MA 2018 Cannabis Open study
Show Cannabidiol Based Medical Cannabis in Children with Autism- a Retrospective Feasibility Study Aran A., Cassuto H., Lubotzky A. 2018 Cannabis;Cannabidiol Open study A CBD-rich cannabis extract may be effective in children with autism
Show HIV/AIDS Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis Brunet L. et al. 2013 Cannabis Open study Cannabis does not increase the risk of liver fibrosis in patients co-infected with HIV and HCV
Show Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study Morris, Madeline A. et al. 2018 Cannabis Open study Cannabis use is not associated with increased risks of respiratory diseases.
Show Marijuana use and fecundability in a North American preconception cohort study Wise LA1, Wesselink AK, Hatch EE, Rothman KJ, Mikkelsen EM, Sørensen HT, Mahalingaiah S 2018 Cannabis Open study
Show Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes van Eyk HJ et al. 2018 Open study Caloric restriction in patients with type 2 diabetes reduces endocannabinoid levels
Show The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment Gruber SA, Sagar KA, Dahlgren MK, Gonenc A, Smith RT, Lambros AM, Cabrera KB, Lukas SE 2018 Cannabis Open study The medical use of cannabis improves cognitive performance
Show Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly Abuhasira R, Schleider LB, Mechoulam R, Novack V 2018 Cannabis Open study The medical use of cannabis is safe in elder people
Show HIV/AIDS Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals Manuzak JA et al. 2018 Cannabis Open study Heavy cannabis use in patients with HIV is associated with improved immune function
Show Cancer Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer Bar-Lev Schleider L et al. 2018 Cannabis Open study Cannabis is effective in alleviating symptoms of cancer patients
Show Pain Medical Cannabis for the Treatment of Fibromyalgia Habib G, Artul S. 2018 Cannabis Open study Cannabis may have a beneficial effect on patients with fibromyalgia
Show Pain Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability Cooper ZD, Bedi G, Ramesh D, Balter R, Comer SD, Haney M 2018 Cannabis Open study Cannabis enhances the pain reducing effects of the opioid oxycodone according to experimental study
Show Epilepsy Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia 2018 Cannabidiol Open study About half of children with epilepsy had a significant improvement following CBD treatment
Show Marijuana use and mortality following orthopedic surgical procedures. Moon AS, Smith W, Mullen S, Ponce BA, McGwin G, Shah A, Naranje SM 2018 Cannabis Open study Cannabis use was associated with reduced mortality following orthopaedic surgery
Show Pain Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay Cuñetti L, Manzo L, Peyraube R, Arnaiz J, Curi L, Orihuela S 2018 Cannabidiol Open study CBD may reduce pain in patients with kidney transplants
Show Huntington's disease Cannabinoids for Treatment of Dystonia in Huntington's Disease Saft C, von Hein SM, Lücke T, Thiels C, Peball M, Djamshidian A, Heim B3, Seppi K 2018 Other cannabinoids Open study Cannabinoids may be helpful in the treatment of Huntington's disease
Show Plasma anandamide concentrations are lower in children with autism spectrum disorder Karhson DS et al. 2018 Open study In patients with autism there are low blood concentrations of anandamide
Show Pain Association of Medical and Adult-Use Marijuana Laws With Opioid Prescribing for Medicaid Enrollees Wen H, Hockenberry JM 2018 Cannabis Open study Legalization of cannabis for medical use is associated with reduced prescriptions of opioids
Show Pain Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population Bradford AC, Bradford WD, Abraham A, Bagwell Adams G 2018 Cannabis Open study Legalization of cannabis for medical use is associated with reduced prescriptions of opioids
Show Dependency/withdrawal Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis Socías ME et al. 2017 Cannabis Open study Cannabis use reduced crack use
Show Pain Effects of Legal Access to Cannabis on Scheduled II-V Drug Prescriptions. Stith SS, Vigil JM, Adams IM, Reeve AP 2018 Cannabis Open study Legal access to cannabis may reduce the treatment with other medicinal drugs
Show Tourette's syndrome Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P 2017 Cannabis Open study Cannabis improved symptoms of Tourette syndrome
Show Dependency/withdrawal Hill KP et al. 2017 Nabilone Open study Nabilone reduced cannabis use in cannabis-dependent persons
Show Multiple sclerosis THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study Maniscalco GT et al. 2018 Other cannabinoids Open study Cannabis may be beneficial in overactive bladder of patients with MS according to an observational study
Show Parkinson's disease Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience Balash Y et al. 2017 Cannabis Open study Cannabis may be beneficial in Parkinson`s disease according to a survey
Show HIV/AIDS Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients Nordmann S et al. 2018 Cannabis Open study Daily cannabis use may protect the liver in people with HIV and hepatitis C
Show Multiple sclerosis;Pain Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients Schimrigk S et al. 2017 Other cannabinoids Open study No significant difference between placebo and THC in the treatment of pain of patients with multiple sclerosis
Show Epilepsy Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents - An observational, longitudinal study Hausman-Kedem M, Menascu S, Kramer U 2018 Cannabis Open study A cannabis extract with THC and CBD reduced seizures in epilepsy
Show Anxiety;Depression A naturalistic examination of the perceived effects of cannabis on negative affect Cuttler C, Spradlin A, McLaughlin RJ 2018 Cannabis Open study Acute use of cannabis may reduce anxiety and depression
Show Relation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure Adegbala O et al. 2018 Cannabis Open study Cannabis use was associated with a lower risk of artrial fibrillation
Show Testing associations between cannabis use and subcortical volumes in two large population-based samples Gillespie NA et al. 2018 Open study Cannabis use has no effect on brain structure
Show Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users Beale C et al. 2018 Cannabis Open study CBD repaired negative effects of regular cannabis use on a certain brain region
Show Endocannabinoid system in systemic lupus erythematosus: First evidence for a deranged 2-arachidonoylglycerol metabolism Navarini L et al. 2018 Other cannabinoids Open study Systemic lupus erythematosus was associated with an altered endocannabinoid system
Show Pain Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ 2018 Delta-9-THC Open study Acute pain is reduced by THC
Show Appetite loss/weight loss The Impact of Δ9-THC on the Psychological Symptoms of Anorexia Nervosa: A Pilot Study Avraham Y, Latzer Y, Hasid D, Berry EM 2017 Delta-9-THC Open study THC may improve symptoms of anorexia nervosa
Show Pain Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. Baron EP, Lucas P, Eades J, Hogue O 2018 Cannabis Open study Pain patients often substitute opioids with cannabis
Show Psychosis/schizophrenia The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences Naji L. et al. 2018 Cannabis Open study Cannabis use has no effect on suicidal attempts in psychiatric disorders
Show Multiple sclerosis;Pain Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials. Turri M, Teatini F, Donato F, Zanette G, Tugnoli V, Deotto L, Bonetti B, Squintani G 2018 Other cannabinoids Open study Cannabis reduces pain in multiple sclerosis
Show Pain Medical Cannabis in Patients with Chronic Pain: Effect on Pain Relief, Pain Disability, and Psychological aspects. A Prospective Non randomized Single Arm Clinical Trial. Poli P, Crestani F, Salvadori C, Valenti I, Sannino C. 2017 Cannabis Open study Cannabis tea effective in the treatment of chronic pain
Show Pain Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. Bellnier T, Brown GW, Ortega TR. 2018 Cannabis Open study Cannabis reduces pain and increases the quality of life in pain patients
Show Pain Medical Cannabis Legalization and Opioid Prescriptions: Evidence on US Medicaid Enrollees during 1993-2014. Liang D, Bao Y, Wallace M, Grant I, Shi Y. 2018 Cannabis Open study Legalization of cannabis for medical use in the US is associated with reduced opioid prescriptions
Show Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA. 2018 Cannabis Open study Cannabis use is associated with decreased mortality in hospital after a heart attack
Show Epilepsy Open-label use of Highly* purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes. Devinsky O, et al. 2018 Cannabidiol Open study CBD reduces seizures in several further childhood-onset epilepsy forms according to an open-label study
Show Multiple sclerosis Tetrahydrocannabinol/Cannabidiol Oromucosal Spray in Patients With Multiple Sclerosis: A Pilot Study on the Plasma Concentration-Effect Relationship. Contin M, Mancinelli L, Perrone A, Sabattini L, Mohamed S, Scandellari C, Foschi M, Vacchiano V, Lugaresi A, Riva R. 2018 Delta-9-THC;Cannabidiol Open study Large variation of plasma concentrations of THC and CBD after oral intake
Show Epilepsy Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results. Szaflarski JP, et al. 2018 Cannabidiol Open study CBD was effective in several epilepsy forms in the long-term
Show Sleep disorder Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions. Vigil JM, Stith SS, Diviant JP, Brockelman F, Keeling K, Hall B. 2018 Cannabis Open study The effect of cannabis on insomnia depended on the cannabis variety
Show Pain Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study. Campbell G. et al. 2018 Cannabis Open study Pain patients who use cannabis have greater pain severity than non-users
Show Pain Marijuana's Influence on Pain Scores, Initial Weight Loss, and Other Bariatric Surgical Outcomes. Bauer FL, Donahoo WT, Hollis HW Jr, Tsai AG, Pottorf BJ, Johnson JM, Silveira LJ, Husain FA. 2018 Cannabis Open study Cannabis users need higher doses of opioids after surgery
Show Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents. Bonnet U, Canbay A, Specka M, Scherbaum N. 2018 Cannabis Open study Heavy cannabis use has no relevant influence on liver function
Show Cancer chemotherapy Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: A multicenter, retrospective review. Polito S, MacDonald T, Romanick M, Jupp J, Wiernikowski J, Vennettilli A, Khanna M, Patel P, Ning W, Sung L, Dupuis LL. 2018 Delta-9-THC Open study Nabilone is well tolerated in children undergoing chemotherapy
Show Medical marijuana laws and workplace fatalities in the United States. Anderson DM, Rees DI, Tekin E. 2018 Cannabis Open study Medical cannabis laws in the USA are associated with improved workplace safety
Show Dependency/withdrawal Falling rates of marijuana dependence among heavy users. Davenport S. 2018 Cannabis Open study The risk of dependence formation among heavy cannabis users in the USA declined in the past 15 years
Show Epilepsy Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study. Szaflarski JP, Bebin EM, Cutter G, DeWolfe J, Dure LS, Gaston TE, Kankirawatana P, Liu Y, Singh R, Standaert DG, Thomas AE, Ver Hoef LW; UAB CBD Program. 2018 Cannabidiol Open study Large study with CBD in patients with epilepsy demonstrates good long-term safety of the medication
Show Epilepsy Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience. Chen KA, Farrar M, Cardamone M, Gill D, Smith R, Cowell CT, Truong L, Lawson JA. 2018 Cannabidiol Open study CBD effective in children with epilepsy
Show Pain Self-Reported Effectiveness and Safety of Trokie® Lozenges: A Standardized Formulation for the Buccal Delivery of Cannabis Extracts. Crowley K, de Vries ST, Moreno-Sanz G. 2018 Cannabis Open study Cannabis lozenges reduce pain in an observational study
Show Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography. Hirvonen J, et al. 2018 Open study Tobacco smokers have reduced concentrations of brain CB1 receptors
Show Psychosis/schizophrenia GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Pasman JA, et al. 2018 Cannabis Open study Genetic investigation shows positive influence of schizophrenia risk on cannabis use
Show Pain Medina SH, Nadarajah V, Jauregui JJ, Smuda MP, Foster M, Meredith SJ, Packer JD, Henn RF 3rd. 2018 Cannabis Open study Cannabis use was associated with less pain after orthopaedic surgery
Show Patient-Reported Symptom Relief Following Medical Cannabis Consumption Stith SS, Vigil JM, Brockelman F, Keeling K, Hall B. 2018 Cannabis Open study Cannabis provides symptom relief in a wide range of health conditions
Show Association between the detection of alcohol, illicit drugs and/or psychotropic medications/opioids in patients admitted due to trauma and trauma recidivism: A cohort study. Cordovilla-Guardia S, et al. 2018 Cannabis Open study Alcohol and cannabis use was associated with an increased risk of re-injury
Show Association and Clinical Outcomes of Marijuana in Patients with Intracerebral Hemorrhage. Malhotra K, Rumalla K, Mittal MK. 2018 Cannabis Open study Cannabis use does not increase the risk of stroke due to bleeding in the brain
Show Dependency/withdrawal High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis. Socías ME, Wood E, Lake S, Nolan S, Fairbairn N, Hayashi K, Shulha HP, Liu S, Kerr T, Milloy MJ. 2018 Cannabis Open study Drug addicts have higher retention to opioid replacement treatment if they use cannabis
Show Epilepsy A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome McCoy B. et al. 2018 Delta-9-THC;Cannabidiol Open study Cannabis extract with high CBD and low THC content effective in childhood epilepsy
Show Pain Cannabinoids and spinal cord stimulation for the treatment of failed back surgery syndrome refractory pain. Mondello E, Quattrone D, Cardia L, Bova G, Mallamace R, Barbagallo AA, Mondello C, Mannucci C, Di Pietro M, Arcoraci V, Calapai G. 2018 Delta-9-THC;Cannabidiol Open study Cannabis improves pain in patients with failed back surgery syndrome
Show Appetite loss/weight loss Efficacy and Safety of Appetite-Stimulating Medications in the Inpatient Setting Howard ML, Hossaini R, Tolar C, Gaviola ML. 2018 Delta-9-THC Open study No difference on reduced appetite between THC, megestrol and mirtazapine
Show Joint culpability: The effects of medical marijuana laws on crime Yu-Wei LukeChu & WilburTownsend 2018 Cannabis Open study Medical cannabis laws in the USA not associated with crime
Show Tourette's syndrome Single center experience with medical cannabis in Gilles de la Tourette syndrome Thaler A, Arad S, Schleider LB, Knaani J, Taichman T, Giladi N, Gurevich T. 2018 Cannabis Open study Cannabis is effective in Tourette syndrome according to a survey
Show Cancer Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol Kenyon J, Liu W, Dalgleish A. 2018 Cannabidiol Open study Cannabidiol may be useful in the treatment of cancer according to an observational study
Show Dependency/withdrawal Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA. Destrée L, Amiet D, Carter A, Lee R, Lorenzetti V, Segrave R, Youssef G, Solowij N, Yücel M. 2018 Cannabis Open study The status of legalisation in US states has no effect on problematic cannabis use
Show Dependency/withdrawal;Depression Sex Differences in the Association Between Cannabis Use and Suicidal Ideation and Attempts, Depression, and Psychological Distress Among Canadians. Halladay JE, Boyle MH, Munn C, Jack SM, Georgiades K. 2018 Cannabis Open study Cannabis use may be associated with an increased risk of suicide
Show Bipolar disorders Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. 2016 Cannabis Open study Cannabis may be helpful in bipolar disorder
Show Reduced Incidence and Better Liver Disease Outcomes among Chronic HCV Infected Patients Who Consume Cannabis Adejumo AC, Adegbala OM, Adejumo KL, Bukong TN. 2018 Cannabis Open study Cannabis reduces risk of liver cirrhosis in patients with hepatitis C virus infection
Show Cancer;Cancer chemotherapy Medical Cannabis Use by Hodgkin Lymphoma Patients: Experience of a Single Center Sarid N. et al. 2018 Cannabis Open study Patients with Hodgkin’s lymphoma may profit from a treatment with cannabis
Show Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study. Aran A, Cassuto H, Lubotzky A, Wattad N, Hazan E. 2018 Cannabidiol Open study Cannabis may be helpful in the treatment of children with autism in an open study
Show Pain Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study. Yassin M, Oron A, Robinson D. 2018 Cannabis Open study Cannabis may be beneficial in patients with fibromyalgia and low back pain
Show Should donors who have used marijuana be considered candidates for living kidney donation? Ruckle, D. et al. 2018 Cannabis Open study Cannabis users may be kidney donors
Show Dependency/withdrawal Greater risk for frequent marijuana use and problems among young adult marijuana users with a medical marijuana card. Tucker JS, Rodriguez A, Pedersen ER, Seelam R, Shih RA, D'Amico EJ. 2018 Cannabis Open study Adolescents, who are allowed to use medical cannabis, use cannabis more often
Show Alcohol and Cannabis Use Alter Pulmonary Innate Immunity. 2018 Cannabis Open study Smoking of cannabis may promote airway inflammation
Show Effects of chronic marijuana use on driving performance Doroudgar S, Mae Chuang H, Bohnert K, Canedo J, Burrowes S, Perry PJ. 2018 Cannabis Open study Regular cannabis users had lower driving abilities
Show Spasticity;Multiple sclerosis;Pain;Tremor;Depression The perceived effects of smoked cannabis on patients with multiple sclerosis. Consroe P, Musty R, Rein J, Tillery W, Pertwee R 1997 Cannabis Survey In more than 80% improvement of spasticity, pain, tremor, depression, anxiety, and paresthesia
Show Parkinson's disease Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Venderova K, Ruzicka E, Vorisek V, Visnovsky P. 2004 Cannabis Survey 25% of the respondents had taken cannabis and 45.9% of these described some form of benefit.
Show Pain Cannabis use for chronic non-cancer pain: results of a prospective survey. Ware MA, Doyle CR, Woods R, Lynch ME, Clark AJ 2003 Cannabis Survey Cannabis use is prevalent among the chronic non-cancer pain population
Show Tourette's syndrome Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome. Muller-Vahl KR, Kolbe H, Schneider U, Emrich HM. 1998 Cannabis Survey Evidence that marijuana improves tics and behavioural disorders in TS.
Show Spasticity;Spinal cord injury Cannabis effect on spasticity in spinal cord injury. Malec J, Harvey RF, Cayner JJ. 1982 Cannabis Survey Decreased spasticity with marijuana use
Show Nausea/vomiting;Cancer chemotherapy Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes. Doblin RE, Kleiman MA. 1991 Cannabis Survey 54% of oncologists thought marijuana should be available on prescription
Show Nausea/vomiting;Cancer chemotherapy Marijuana to prevent nausea and vomiting in cancer patients: a survey of clinical oncologists. Schwartz RH, Voth EA, Sheridan MJ. 1997 Cannabis Survey Only a small percentage of oncologists prescribed marijuana
Show Spasticity;Spinal cord injury;Pain The perceived effects of marijuana on spinal cord injured males. Dunn M, Davis R. 1974 Cannabis Survey Decrease in pain and spasticity.
Show Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS;Pain;Anxiety Cannabis use in HIV for pain and other medical symptoms. Woolridge E, Barton S, Samuel J, Osorio J, Dougherty A, Holdcroft A. 2005 Cannabis Survey 27% used cannabis for the treatment of various symptoms
Show Pain;Depression;Anxiety Cannabis use in sickle cell disease: a questionnaire study. Howard J, Anie KA, Holdcroft A, Korn S, Davies SC. 2005 Cannabis Survey 36% had used cannabis to treat symptoms
Show Spasticity;Multiple sclerosis;Pain;Depression Cannabis use as described by people with multiple sclerosis. Page SA, Verhoef MJ, Stebbins RA, Metz LM, Levy JC. 2003 Cannabis Survey Improvement of pain, spasticity and anxiety/depression
Show Appetite loss/weight loss;HIV/AIDS;Pain;Depression Patterns of marijuana use among patients with HIV/AIDS followed in a public health care setting. Prentiss D, Power R, Balmas G, Tzuang G, Israelski DM. 2004 Cannabis Survey Improvement of pain, appetite and depression/anxiety by using cannabis
Show Appetite loss/weight loss;Spasticity;Pain;Depression Survey of cannabis use in patients with amyotrophic lateral sclerosis. Amtmann D, Weydt P, Johnson KL, Jensen MP, Carter GT. 2004 Cannabis Survey Moderate improvement of pain, spasticity, appetite and depression
Show Dependency/withdrawal Low efficacy of non-opioid drugs in opioid withdrawal symptoms. Hermann D, Klages E, Welzel H, Mann K, Croissant B. 2005 Cannabis Survey Only low efficacy of cannabis in alleviating opioid withdrawal symptoms
Show Nausea/vomiting Survey of medicinal cannabis use among childbearing women: patterns of its use in pregnancy and retroactive self-assessment of its efficacy against 'morning sickness'. Westfall RE, Janssen PA, Lucas P, Capler R. 2006 Cannabis Survey Cannabis effective against nausea and vomiting
Show Spasticity;Multiple sclerosis;Pain Cannabis use in patients with multiple sclerosis. Chong MS, Wolff K, Wise K, Tanton C, Winstock A, Silber E. 2006 Cannabis Survey A subgroup of patients with severe disabilitiy appears to derive some benefit
Show Long term marijuana users seeking medical cannabis in California (2001-2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants. O'Connell TJ, Bou-Matar CB. 2007 Cannabis Survey
Show The medicinal use of cannabis in the UK: results of a nationwide survey. Ware MA, Adams H, Guy GW. 2005 Cannabis Survey Cannabis use was reported by 25 % of patients with chronic pain and 22 % of patients with multiple sclerosis
Show Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS Marijuana Use in HIV-Positive and AIDS Patients: Results of an Anonymous Mail Survey Sidney S. 2001 Cannabis Survey 22.4 % used cannabis for medicinal purposes
Show Survey on the medical use of cannabis and THC in Germany. Grotenhermen F, Schnelle M. 2003 Cannabis;Delta-9-THC Survey Cannabis and THC were effective in many conditions
Show Clinical improvement and reduction of immunosuppressive drug therapy in cannabis treated patients with crohn's disease. Hergenrather JY, Mikuriya TH, Bearman D. 2005 Cannabis Survey The majority of patients found a substantial improvement of their symptoms
Show Nausea/vomiting;HIV/AIDS;Pain;Depression;Anxiety Marijuana Effectiveness as an HIV Self-Care Strategy. Corless IB, Lindgren T, Holzemer W, Robinson L, Moezzi S, Kirksey K, Coleman C, Tsai YF, Sanzero Eller L, Hamilton MJ, Sefcik EF, Canaval GE, Rivero Mendez M, Kemppainen JK, Bunch EH, Nicholas PK, Nokes KM, Dole P, Reynolds N. 2009 Cannabis Survey Participants rated cannabis as similar effective as other medications for the treatment of their symptoms.
Show Relief oriented use of marijuana by teens. Bottorff JL, Johnson JL, Moffat BM, Mulvogue T. 2009 Cannabis Survey 20 participants said that they used cannabis to treat health problems.
Show Increased Blood Pressure Following Abrupt Cessation of Daily Cannabis Use. Vandrey R, Umbricht A, Strain EC. 2011 Cannabis;Nabilone Survey In 6 of 13 subjects blood pressure increased significantly after cessation of cannabis use.
Show The relationship between substance use and posttraumatic stress disorder in a methadone maintenance treatment program. Villagonzalo KA, Dodd S, Ng F, Mihaly S, Langbein A, Berk M. 2010 Cannabis Survey Cannabis may be used to self-treat posttraumatic stress disorder (PTSD)
Show Bipolar disorders Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. Ringen PA, Vaskinn A, Sundet K, Engh JA, Jónsdóttir H, Simonsen C, Friis S, Opjordsmoen S, Melle I, Andreassen OA. 2010 Cannabis Survey In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects.
Show Dependency/withdrawal Cannabis as a substitute for alcohol and other drugs Reiman A. 2009 Cannabis Survey 40 % use cannabis to substitute for alcohol, 26 % to substitute for illegal drugs
Show Gastrointestinal disorder;Inflammation Cannabis use amongst patients with inflammatory bowel disease. Lal S, Prasad N, Ryan M, Tangri S, Silverberg MS, Gordon A, Steinhart H. 2011 Cannabis Survey Cannabis use is frequent in patients with chronic intestinal inflammation
Show PTSD contributes to teen and young adult cannabis use disorders. Cornelius JR, Kirisci L, Reynolds M, Clark DB, Hayes J, Tarter R. 2010 Cannabis Survey People with PTSD have a higher risk for cannabis use
Show Cancer A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT. 2009 Cannabis Survey Subjects who used cannabis had a reduced cancer risk.
Show The medicinal use of cannabis and cannabinoids: an international survey on methods of intake. Hazekamp A, Grotenhermen F, Abrams D, Russo E, Ware M, Navarrete-Varo R, Brenneisen R, Müller-Vahl K. 2011 Cannabis;Delta-9-THC;Nabilone Survey Preferred modes of use were smoking of cannabis (62.9 per cent), inhalation of cannabis with a vaporizer (23.6 per cent), oral use of cannabis in baked goods (7.9 per cent), oral use of cannabis as a tea (2.4 per cent), and oral use of dronabinol/Marinol (1.8 per cent).
Show Pain Herbal cannabis use in patients labeled as fibromyalgia is associated with negative psychosocial parameters. Ste-Marie PA, Fitzcharles MA, Gamsa A, Ware MA, Shir Y. 2012 Cannabis Survey Many patients with fibromyalgia use cannabis products.
Show Multiple sclerosis;Pain;Spasticity A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine. Notcutt WG. 2012 Cannabis Survey Most respondents experienced improvements across a range of symptoms.
Show Dependency/withdrawal Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients. Lucas P, Reiman A, Earleywine M, McGowan S, Oleson M, Coward M, Thomas B. 2013 Cannabis Survey Many patients substitute cannabis for alcohol, illegal and medicinal drugs
Show Profiles of medicinal cannabis patients attending compassion centers in rhode island. Zaller N, Topletz A, Frater S, Yates G, Lally M. 2015 Cannabis Survey Most participants report that medicinal cannabis improves their pain symptomology.
Show Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples Alshaarawy O, Anthony JC. 2015 Cannabis Survey Cannabis use was associated with a 30% reduction of diabetes risk
Show Pain Experience of adjunctive cannabis use for chronic non-cancer pain: Findings from the Pain and Opioids IN Treatment (POINT) study. Degenhardt L, Lintzeris N, Campbell G, Bruno R, Cohen M, Farrell M, Hall WD. 2015 Cannabis Survey Pain patients, who receive opioids, experience better pain relief if they also take cannabis.
Show Posttraumatic stress disorder Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Bonn-Miller MO, Babson KA, Vandrey R. 2014 Cannabis Survey Patients with high PTSD scores were more likely to use cannabis to improve sleep, and for coping reasons more generally.
Show Gastrointestinal disorder;Inflammation Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease. Ravikoff Allegretti J, Courtwright A, Lucci M, Korzenik JR, Levine J. 2013 Cannabis Survey Patients find cannabis very helpful for symptom control.
Show Epilepsy Cannabis and other illicit drug use in epilepsy patients. Hamerle M, Ghaeni L, Kowski A, Weissinger F, Holtkamp M. 2014 Cannabis Survey The use of cannabis did not affect disease severity in epilepsy.
Show Headache/migraine Use of cannabis among 139 cluster headache sufferers. Leroux E, Taifas I, Valade D, Donnet A, Chagnon M, Ducros A. 2013 Cannabis Survey Less than one third of self-reported users mention a relief of their attacks following inhalation.
Show Epilepsy Marijuana use in adults admitted to a Canadian epilepsy monitoring unit. Massot-Tarrús A, McLachlan RS. 2016 Cannabis Survey Improvement in seizures, stress was decreased, sleep improved and memory/concentration was better
Show Association of State Recreational Marijuana Laws With Adolescent Marijuana Use Cerdá M, Wall M, Feng T, Keyes KM, Sarvet A, Schulenberg J, O'Malley PM, Pacula RL, Galea S, Hasin DS 2017 Cannabis Survey Mixed consequences of cannabis legalization on cannabis use by adolescents
Show Pain Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana (Cannabinoids) for Treatment of Pain: A Prospective Population Survey Khelemsky Y et al. 2017 Cannabis Survey More than 80% of patients believe that cannabis may reduce pain
Show Spinal cord injury Cannabis use in persons with traumatic spinal cord injury in Denmark Andresen SR, Biering-Sørensen F, Hagen EM, Nielsen JF, Bach FW, Finnerup NB 2017 Cannabis Survey Cannabis use is more frequent among people with spinal cord injury than among the general population
Show Depression Depression and marijuana use disorder symptoms among current marijuana users Dierker L, Selya A, Lanza S, Li R3, Rose J 2018 Cannabis Survey People with depression more often use cannabis
Show Pain Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts Heng, Marilyn et al. 2017 Cannabis;Other cannabinoids Survey Trauma patients find relief from a treatment with cannabis according to a survey
Show Parkinson's disease Cannabis use in people with Parkinson's disease and Multiple Sclerosis: A web-based investigation Kindred JH, Li K, Ketelhut NB, Proessl F, Fling BW, Honce JM, Shaffer WR, Rudroff T 2017 Cannabis Survey Cannabis may be helpful in Parkinson’s disease according to a survey
Show Cannabis as a substitute for prescription drugs - a cross-sectional study Corroon JM Jr, Mischley LK, Sexton M 2017 Cannabis Survey Cannabis is used as a substitute for prescription drugs according to a large survey
Show Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical cannabis patients Lucas P, Walsh Z 2017 Cannabis Survey Patients prefer cannabis over opioids
Show Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness. Schuster RM, Fontaine M, Nip E, Zhang H, Hanly A, Evins AE 2017 Cannabis Survey Prolonged withdrawal symptoms in young cannabis users with psychiatric diseases
Show Childhood academic ability in relation to cigarette, alcohol and cannabis use from adolescence into early adulthood: Longitudinal Study of Young People in England (LSYPE). Williams J, Hagger-Johnson G 2017 Cannabis Survey High academic ability reduced the risk of tobacco smoking but increased the risk of cannabis use in adolescents
Show Pain Chronic pain patients' perspectives of medical cannabis Piper BJ, Beals ML, Abess AT, Nichols SD, Martin M, Cobb CM, DeKeuster RM. 2017 Cannabis Survey Medical cannabis patients rate cannabis as very effective
Show Cannabis use patterns and motives: A comparison of younger, middle-aged, and older medical cannabis dispensary patients. Haug NA, Padula CB, Sottile JE, Vandrey R, Heinz AJ, Bonn-Miller MO 2017 Cannabis Survey : Low age associated with higher problematic cannabis use among medical cannabis users
Show Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study. Adejumo AC et al. 2017 Cannabis Survey Cannabis use is associated with a lower prevalence of non-alcoholic fatty liver disease according to a large study
Show Pain Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts. Heng M, McTague MF, Lucas RC, Harris MB, Vrahas MS, Weaver MJ 2018 Cannabis Survey Patients believe that medical marijuana is a valid treatment and that it does have a role in reducing postinjury and postoperative pain.
Show Spinal cord injury Cannabis Use in Individuals With Spinal Cord Injury or Moderate to Severe Traumatic Brain Injury in Colorado Hawley LA, Ketchum JM, Morey C, Collins K, Charlifue S 2018 Cannabis Survey A high number of patients with spinal cord injury and traumatic brain injury use cannabis
Show Anxiety;Pain;Sleep disorder Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep Piper BJ et al. 2018 Cannabis Survey Patients who use cannabis reduce their use in medications for pain, anxiety, migraine and sleep disorders
Show HIV/AIDS Association of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men Adams, Joëlla W. et al. 2018 Cannabis Survey Cannabis use has no effect on the mortality of HIV-infected men
Show Pain Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy Nugent SM et al. 2018 Cannabis Survey Cannabis use in pain patients was associated with a higher risk for opioid misuse
Show Marijuana Use is Protective in Burns Williams F, Chrisco L, Nizamani R, Cairns B, Jones S 2018 Cannabis Survey Cannabis use reduces mortality in patients with burns
Show Multiple sclerosis Effect of tetrahydrocannabinol:cannabidiol oromucosal spray on activities of daily living in multiple sclerosis patients with resistant spasticity: a retrospective, observational study. Mallada Frechín J. 2018 Other cannabinoids Survey A cannabis spray has positive effects on activities of daily living in patients with Multiple Sclerosis
Show Cancer Many cancer patients use cannabis in Canada Martell K, Fairchild A, LeGerrier B, Sinha R, Baker S, Liu H, Ghose A, Olivotto IA, Kerba M. 2018 Cannabis Survey Many cancer patients use cannabis in Canada
Show Posttraumatic stress disorder Cannabis Use Disorder and Post-Deployment Suicide Attempts in Iraq/Afghanistan-Era Veterans Adkisson K, Cunningham KC, Dedert EA, Dennis MF, Calhoun PS, Elbogen EB, Beckham JC, Kimbrel NA. 2018 Cannabis Survey Cannabis dependence was associated with an increased risk of suicide in war veterans
Show Marijuana Use in Adults Living with Sickle Cell Disease. Roberts JD, Spodick J, Cole J, Bozzo J, Curtis S, Forray A. 2018 Cannabis Survey Cannabis may have therapeutic effects in patients with sickle cell disease
Show Anxiety;Depression;Pain;Sleep disorder A Cross-Sectional Study of Cannabidiol Users. Corroon J, Phillips JA. 2018 Cannabidiol Survey CBD is mostly used against pain, sleep disorders, anxiety and depression
Show Epilepsy Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community Suraev A. et al. 2018 Cannabis Survey THC and CBD content in products used for self-treatment of Australian children with epilepsy varies considerably
Show Medicinal cannabis in Australia, 2016: the Cannabis as Medicine Survey (CAMS-16). Lintzeris N, Driels J, Elias N, Arnold JC, McGregor IS, Allsop DJ. 2018 Cannabis Survey Results of a survey among Australian patients, who treat themselves with cannabis
Show The Association Between Tetrahydrocannabinol and Lower Urinary Tract Symptoms Utilizing the National Health and Nutrition Examination Survey. Fantus RJ, Riedinger CB, Chang C, Helfand BT. 2018 Delta-9-THC Survey Cannabis use is protective against lower urinary tract symptoms
Show Pain The Consumption of Cannabis by Fibromyalgia Patients in Israel. Habib G, Avisar I. 2018 Cannabis Survey Many patients with fibromyalgia profit from a treatment with cannabis according to survey
Show Attention-deficit/hyperactivity disorder ADHD, depression, and substance abuse risk among beginning college students. Mochrie KD, Whited MH, Cellucci T, Freeman T, Corson AT. 2018 Cannabis Survey Students with ADHD are more likely to use cannabis
Show The relationship between cannabis use and diabetes: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III Imtiaz S, Rehm J. 2018 Cannabis Survey Cannabis use is associated with significant reduction in occurrence of diabetes
Show Dependency/withdrawal DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults Livne O., Shmulewitz D., Lev-Ran S., Hasin D. 2018 Cannabis Survey Cannabis withdrawal syndrome is found in 12% of frequent users
Show Pain The Impact of Cannabis Access Laws on Opioid Prescribing McMichael, Benjamin J. and Van Horn, Ray and Viscusi, W. Kip 2018 Cannabis Survey Cannabis laws in the USA are associated with reduced opioid prescriptions
Show Dependency/withdrawal A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age. Sexton M, Cuttler C, Mischley LK. 2018 Cannabis Survey Differences between medical and recreational cannabis users with regard to withdrawal
Show Epilepsy Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy Aguirre-Velázquez CG 2017 Cannabis Survey;Basic research CBD-rich cannabis reduced seizures in children with epilepsy according to a survey
Show Nausea/vomiting;Cancer chemotherapy;Pain Cannabinoids in the management of intractable chemotherapy-induced nausea and vomiting and cancer-related pain. Sutton IR, Daeninck P. 2006 Nabilone Survey;Uncontrolled case report Significant improvement in one case of intractable neuropathic pain and one case of refractory cinv
Show Nausea/vomiting;Cancer;Cancer chemotherapy Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol). Gonzalez-Rosales F, Walsh D 1997 Delta-9-THC Uncontrolled case report patients was treated with several antiemetic drugs, but it was not until dronabinol was added that the nausea and vomiting stopped
Show Epilepsy Anticonvulsant nature of marihuana smoking. Consroe PF, Wood GC, Buchsbaum H 1975 Cannabis Uncontrolled case report Cannabis was able to control seizures in conjunction with phenobarbital and diphenylhydantoin.
Show Spasticity;Pain Marihuana as a therapeutic agent for muscle spasm or spasticity. Petro DJ 1980 Cannabis Uncontrolled case report Relief from spasticity and pain
Show Spasticity;Dystonia;Epilepsy;Anxiety Experiences with THC-treatment in children and adolescents Lorenz R 2003 Delta-9-THC Uncontrolled case report Positive effects of THC in children with severe neurological disorders
Show Bipolar disorders The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research. Grinspoon L, Bakalar JB. 1998 Cannabis Uncontrolled case report A number of patients find cannabis (marihuana) useful in the treatment of their bipolar disorder
Show Dependency/withdrawal Cannabis substitution. An adjunctive therapeutic tool in the treatment of alcoholism. Mikuriya TH 1970 Cannabis Uncontrolled case report Marijuana consumption may help to decrease alcolholic intake.
Show Dystonia Treatment of Meige's syndrome with cannabidiol. Snider S.R, Consroe P. 1984 Cannabidiol Uncontrolled case report 50% improvement in spasm severity and frequency
Show Pain A case of cannabinoid rotation in a young woman with chronic cystitis Krenn H Daha LK Oczenski W Fitzgerald R D 2003 Delta-9-THC;Nabilone Uncontrolled case report THC reduced pain with low side effects; nabilone caused strong psychic side effects
Show Dystonia Cannabidiol in dystonic movement disorders. Sandyk R, Snider SR, Consroe P, Elias SM. 1986 Cannabidiol Uncontrolled case report Cannabidiol (CBD) reduced dystonic movements
Show Tourette's syndrome Treatment of Tourette's syndrome with delta-9-tetrahydrocannabinol. Muller-Vahl KR, Schneider U, Kolbe H, Emrich HM. 1999 Delta-9-THC Uncontrolled case report Improvement of tics and obsessive-compulsive behavior
Show Parkinson's disease Beneficial and adverse effects of cannabidiol in a Parkinson patient with sinemet-induced dystonic dyskinesia. Snider SR, Consroe P. 1985 Cannabidiol Uncontrolled case report Improvement of dyskinesia
Show Pain [Tetrahydrocannabinol for treatment of chronic pain] [Article in German] Elsner F, Radbruch L, Sabatowski R. 2001 Delta-9-THC Uncontrolled case report Sufficient pain relief in three patients
Show Pain Cannabis reduces opioid dose in the treatment of chronic non-cancer pain. Lynch ME, Clark AJ. 2003 Cannabis Uncontrolled case report Improvement in pain, spasticity, bladder spasm, and sleep.
Show Epilepsy Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature. Mortati K, Dworetzky B, Devinsky O. 2007 Cannabis Uncontrolled case report Significant improvement of epilepsy with the use of cannabis.
Show [Fitness to drive in spite (because) of THC] [Article in German] Strohbeck-Kühner P, Skopp G, Mattern R. 2007 Cannabis Uncontrolled case report Significant improvement of driving-related performance
Show Nausea/vomiting Use of medical marijuana for treatment of severe intractable nausea after laparoscopic Roux-en-Y gastric bypass surgery: case report. Merriman AR, Oliak DA. 2008 Delta-9-THC Uncontrolled case report THC relieved nausea refractory to other medications
Show Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension: a case report. Raby WN, Modica PA, Wolintz RJ, Murtaugh K. 2006 Cannabis;Delta-9-THC Uncontrolled case report Improvement of signs and symptoms of the disease
Show Spasticity;Spinal cord injury [Respiratory failure due to delta-9-tetrahydrocannabinol in a tetraplegic patient.]. [Article in German] Neuburger M, Schley M, Schmelz M, Schuepfer G, Konrad C. 2006 Delta-9-THC Uncontrolled case report Dronabinol reduced spasticity but worsened respiration
Show Improvement in refractory obsessive compulsive disorder with dronabinol. Schindler F, Anghelescu I, Regen F, Jockers-Scherubl M. 2008 Delta-9-THC Uncontrolled case report Significant symptom improvement
Show Spasticity A casuistic rationale for the treatment of spastic and myocloni in a childhood neurodegenerative disease: neuronal ceroid lipofuscinosis of the type Jansky-Bielschowsky. Lorenz R. 2002 Delta-9-THC Uncontrolled case report Improvement of spasticity
Show Nausea/vomiting;HIV/AIDS Nabilone as effective therapy for intractable nausea and vomiting in AIDS. Green ST, Nathwani D, Goldberg DJ, Kennedy DH. 1989 Nabilone Uncontrolled case report Intractable nausea and vomiting was effectively relieved with nabilone
Show Alzheimer's disease The cannabinoid receptor agonist nabilone for the treatment of dementia-related agitation. Passmore MJ. 2008 Nabilone Uncontrolled case report Dramatic reduction in the severity of agitation and other behavioural symptoms
Show Bipolar disorders The effect of extreme marijuana use on the long-term course of bipolar I illness: a single case study. El-Mallakh RS, Brown C. 2007 Cannabis Uncontrolled case report Cannabis decreased the number of depressed days and increased the number of hypomanic days.
Show Dependency/withdrawal Use of dronabinol for cannabis dependence: two case reports and review. Levin FR, Kleber HD. 2008 Delta-9-THC Uncontrolled case report THC reduced withdrawal symptoms in cannabis dependence
Show Hiccups Marijuana for intractable hiccups. Gilson I, Busalacchi M. 1998 Cannabis Uncontrolled case report Smoking cannabis stopped hiccups that did not respond to usual medications on the 8th day
Show Tourette's syndrome Marijuana and Tourette’s syndrome. Sandyk R, Awerbuch G. 1988 Cannabis Uncontrolled case report The patients notes a significant amelioration of symptoms when smoking cannabis
Show Tourette's syndrome Effective treatment of Tourette’s syndrome with marijuana. Hemming M, Yellowlees PM. 1993 Cannabis Uncontrolled case report Improvement of symptoms with cannabis
Show Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis E. Russo, M.L. Mathre, A. Byrne, R. Velin, P.J. Bach, J. Sanchez-Ramos, K.A. Kirlin 2002 Cannabis Uncontrolled case report Effective treatment of different serious conditions with cannabis
Show Dependency/withdrawal Cannabis as a Substitute for Alcohol: A Harm-Reduction Approach Mikuriya TH 2004 Cannabis;Nabilone Uncontrolled case report Cannabis is a successful substituent of alcohol
Show Nausea/vomiting Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat? Curry W-NL 2002 Cannabis Uncontrolled case report Cannabis effective in treating nausea and vomiting in pregnant women
Show Appetite loss/weight loss;Spasticity;Pain Marijuana in the management of amyotrophic lateral sclerosis. Carter GT, Rosen BS. 2001 Cannabis Uncontrolled case report Cannabis relieved several symptoms of ALS
Show HIV/AIDS Differential Effects of Medical Marijuana Based on Strain and Route of Administration: A Three-Year Observational Study Corral VL 2001 Cannabis Uncontrolled case report
Show Hemp for headache: An in-depth historical and scientific review of cannabis in migraine treatment. Russo EB 2001 Cannabis Uncontrolled case report Cannabis may be effective in the treatment of headache
Show Cannabis treatments in obstetrics and gynecology: A historical review. Russo E. 2002 Cannabis Uncontrolled case report Cannabis was effective in a wide range of gynecological conditions
Show Tourette's syndrome Müller-Vahl KR, Schneider U, Emrich HM. Combined treatment of Tourette syndrome with delta-9-THC and dopamine receptor agonists. 2002 Delta-9-THC Uncontrolled case report THC may be combined with neuroleptics
Show Treatment of a hyperkinetic movement disorder during pregnancy with dronabinol. Farooq MU, Ducommun E, Goudreau J. 2009 Delta-9-THC Uncontrolled case report Improvement of her hyperkinetic movement disorder with no signs of tolerance
Show Headache/migraine Cluster attacks responsive to recreational cannabis and dronabinol. Robbins MS, Tarshish S, Solomon S, Grosberg BM. 2009 Cannabis;Delta-9-THC Uncontrolled case report Cannabis and THC aborted attacks of headaches.
Show Appetite loss/weight loss;Cancer;Nausea/vomiting;Pain;Spasticity [Cannabinoids in children] [Article in German] Cannabinoide bei Kindern. Gottschling S. 2011 Delta-9-THC Uncontrolled case report Reduced pain, spasticity and improved appetite and nausea
Show Tourette's syndrome Oral Delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report. Hasan A, Rothenberger A, Münchau A, Wobrock T, Falkai P, Roessner V. 2010 Delta-9-THC Uncontrolled case report THC improved tics allowing parallel stimulant treatment of comorbid ADHD.
Show Dystonia Tardive Dystonia and the Use of Cannabis. Beckmann Y, Seçil Y, Güngör B, Yiğit T. 2010 Cannabis;Delta-9-THC Uncontrolled case report Significant improvement by cannabis and dronabinol.
Show Dramatic improvement of refractory Isaacs' syndrome after treatment with dronabinol. Meyniel C, Ollivier Y, Hamidou M, Péréon Y, Derkinderen P. 2010 Delta-9-THC Uncontrolled case report Dramathic improvement of symptoms (profuse sweating, muscular twitching, weight loss)
Show Improvement in refractory psychosis with dronabinol: four case reports. Schwarcz G, Karajgi B. 2010 Delta-9-THC Uncontrolled case report Significant improvement in four patients
Show Cancer Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas-possible role of Cannabis inhalation. Foroughi M, Hendson G, Sargent MA, Steinbok P. 2011 Cannabis Uncontrolled case report Spontaneous regression of benign brain tumour may have been associated with cannabis use.
Show Tourette's syndrome Cannabinoids improve driving ability in a Tourette's patient. Brunnauer A, Segmiller FM, Volkamer T, Laux G, Müller N, Dehning S 2011 Delta-9-THC Uncontrolled case report THC improved driving ability
Show Spasticity;Pain Reposition of a dislocated shoulder under use of cannabis. Schweizer A, Bircher HP. 2009 Cannabis Uncontrolled case report Pain and muscular tone decreased and the shoulder was relocated easily.
Show Posttraumatic stress disorder Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence. Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. 2012 Cannabis Uncontrolled case report Significant improvement in one patient with PSD with cannabis
Show Pain;Spasticity Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report. Vicente-Valor MI, Garcia-Llopis P, Mejia Andujar L, Antonino de la Camara G, García Del Busto N, Lopez Tinoco M, Quintana Vergara B, Peiro Vilaplana C, Dominguez Moran JA, Sánchez Alcaraz A. 2012 Cannabis Uncontrolled case report The cannabis extract was effective in a patient with stiff person syndrome.
Show Posttraumatic stress disorder Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence. Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. 2012 Cannabis Uncontrolled case report Cannabis reduced course and intensity of symptoms.
Show Pain Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%. Hesselink JM, Kopsky DJ. 2012 Cannabis Uncontrolled case report Significant pain improvement with cannabis and ketamine.
Show Dependency/withdrawal Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report. Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW. 2013 Cannabidiol Uncontrolled case report They were no major withdrawal symptoms.
Show Nausea/vomiting Cannabis for intractable nausea after bilateral cerebellar stroke. Adhiyaman V, Arshad S. 2014 Cannabis Uncontrolled case report A woman with intractable nausea after cerebellar stroke responded well to a treatment with THC.
Show Multiple sclerosis Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report. Stroet A, Trampe N, Chan A. 2013 Cannabis Uncontrolled case report A combination of baclofen injections into the cerebrospinal fluid and very low doses of the cannabis extract Sativex was highly effective.
Show Epilepsy Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. Hegde M, Santos-Sanchez C, Hess CP, Kabir AA, Garcia PA. 2012 Cannabis Uncontrolled case report Patients with epilepsy were able to control their seizures by the use of cannabis.
Show Dependency/withdrawal;Pain The prescription of medical cannabis by a transitional pain service to wean a patient with complex pain from opioid use following liver transplantation: a case report. Meng H, Hanlon JG, Katznelson R, Ghanekar A, McGilvray I, Clarke H. 2015 Cannabis Uncontrolled case report The use of cannabis reduced opioid consumption
Show Epilepsy Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases. Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED. 2016 Cannabidiol Uncontrolled case report Cannabidiol is effective in febrile infection-related epilepsy syndrome in a case series
Show Cancer Medical Cannabis in the Palliation of Malignant Wounds—A Case Report Maida V. 2017 Cannabis Uncontrolled case report Topical application of a cannabis extract helpful in cancer wound
Show Tourette's syndrome Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients Jakubovski E, Müller-Vahl K 2017 Cannabis;Delta-9-THC Uncontrolled case report Speechlessness in Tourette syndrome may be treated with cannabis/THC according to case reports
Show Pain Topical Medical Cannabis: A New Treatment for Wound Pain-Three Cases of Pyoderma Gangrenosum Maida V, Corban J 2017 Cannabis Uncontrolled case report Topical cannabis reduced wound pain in a small case series
Show Amyotrophic lateral sclerosis Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report Nahler G. 2017 Cannabidiol Uncontrolled case report Cannabidiol slowed progression of amyotrophic lateral sclerosis in a case report
Show Cannabis for restless legs syndrome: a report of six patients Megelin T., Ghorayeb I. 2017 Cannabis Uncontrolled case report Cannabis may be helpful in restless legs syndrome according to case reports
Show Tourette's syndrome Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P 2017 Cannabis Uncontrolled case report Cannabis effective in Tourette syndrome in case series
Show Obsessive compulsive disorder Refractory OCD Due to Thalamic Infarct With Response to Dronabinol Cooper JJ, Grant J 2017 Delta-9-THC Uncontrolled case report
Show Beneficial Effect of Medical Cannabis in the Treatment of a Pharmacoresistant Nausea Associated with a Somatoform Disorder in a Patient with Post-Polio Syndrome Bleckwenn M, Weckbecker K, Voss S 2018 Cannabis Uncontrolled case report Cannabis improved nausea in a patient with post-polio syndrome
Show Epilepsy The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy Warren PP, Bebin EM, Nabors LB, Szaflarski JP 2017 Cannabidiol Uncontrolled case report CBD may be effective in epilepsy due to brain tumours according to a case series
Show Tourette's syndrome Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report. Pichler EM, Kawohl W, Seifritz E, Roser P. 2018 Delta-9-THC;Cannabidiol Uncontrolled case report A case report suggests that CBD may be beneficial in Tourette syndrome
Show Cannabinoid concentrations in blood and urine after smoking cannabidiol joints. Meier U, Dussy F, Scheurer E, Mercer-Chalmers-Bender K, Hangartner S. 2018 Cannabidiol Uncontrolled case report CBD blood concentrations after smoking CBD cigarettes
Show Pain Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases. Schräder NHB, Duipmans JC, Molenbuur B, Wolff A, Jonkman MF. 2018 Delta-9-THC;Cannabidiol Uncontrolled case report Cannabis effective against pain due to epidermolysis bullosa according to case reports

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