[Back to Overwiew]  [IACM Homepage]


IACM-Bulletin of 22 July 2007

Science: Rimonabant suggested for the treatment of cannabis addiction

The cannabinoid receptor antagonist rimonabant (Acomplia) attenuated the psychological effects of cannabis in a study by researchers of the National Institute on Drug Abuse of the USA with 42 healthy subjects. Authors suggested that the drug may have a "therapeutic potential for a wide range of addictions, including cannabis dependence."

The participants took rimonabant at a daily dose of 40 mg for 15 days. On days 8 and 15 they smoked a cannabis cigarette two hours after intake of rimonabant. The subjective effects and the increase of heart rate by cannabis were significantly reduced by rimonabant on day 8. On day 15 subjective effects were not decreased significantly by rimonabant compared to placebo, which may be indicative of the development of tolerance.

Rimonabant is available in EURopean countries for the treatment of obesity under the name Acomplia, since it reduces appetite. An advisory panel to the US authority for the approval of medicinal drugs (FDA, Food and Drug Administration) recently said that the drug should not be approved in the USA because the manufacturer Sanofi-Aventis has not shown that the benefits outweigh the risk of suicidal thoughts among those taking rimonabant.

(Source: Huestis MA, Boyd SJ, Heishman SJ, Preston KL, Bonnet D, Le Fur G, Gorelick DA. Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users. Psychopharmacology (Berl) 2007 Jul 10; [Electronic publication ahead of print])

News in brief

Science: Epilepsy
Scientists of the Departments of Neurology of the New York University reported about a 45-year-old man with cerebral palsy and epilepsy who showed marked improvement with the use of cannabis. They write that "this case supports other anecdotal data suggesting that marijuana use may be a beneficial adjunctive treatment in some patients with epilepsy." (Source: Mortati K, et al. Rev Neurol Dis 2007;4(2):103-6.)

USA: Federal drug agency (DEA)
The Drug Enforcement Administration (DEA) has sent letters to more than 150 Los Angeles property owners, telling them that they risk arrest, up to 20 years in prison, and the loss of their property if they continue to allow their buildings to be used for "unlawfully … distributing or using a controlled substance." The Los Angeles Times called these letters to owners of buildings with medical cannabis clubs a "deplorable new bullying tactic". (Source: Los Angeles Times of 19 July 2007

USA: Hillary Clinton
Hillary Clinton of the Democratic Party, who wants to become the next president of the United States in 2008, called for an end to federal raids in states where the medical use of cannabis is legal, as most other candidates of the Democrats already did. On July 13 she was told during an event, "Twelve states allow medical marijuana, but the Bush administration continues to raid patients," to which she responded, "Yes, I know. It's terrible." Then she was asked, "Would you stop the federal raids?" Senator Clinton responded firmly, "Yes, I will." (Source: Press release of MPP of 17 July 2007)

Science: Pain
Researchers at Novartis in Basel, Switzerland, developed a CB1 receptor agonist with the name naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone, with limited brain penetration. Thus, the substance, which also binds to the CB2 receptor may have a potential of the treatment of pain without causing relevant psychological effects. (Source: Dziadulewicz EK, et al. J Med Chem 2007 Jul 14; [Electronic publication ahead of print]).

A glimpse @ the past

One year ago

Two years ago

[Back to Overwiew]  [IACM Homepage]


up

Free Online Events 2020

You can find all information here.

The IACM is holding a free webinar series and a free anniversary online meeting from October to November 2020

All webinars will be held in English with subtitles in German, French, Spanish, and Portuguese. All webinars will be available online until March 2021

The anniversary online meeting to celebrate the IACM's 20th anniversary and to honour the 90th birthday of Raphael Mechoulam will be a live session only on the 5th November 2020.

The speakers in the webinar series are Donald I. Abrams, Bonni Goldstein, Franjo Grotenhermen, Manuel Guzmán, Raphael Mechoulam, Kirsten Müller-Vahl, Roger Pertwee, Daniele Piomelli, and Ethan Russo.

You can find all information here.

Please become a member of the IACM to financially support free events like these and other activities of the IACM.

IACM Conference 2021

The 12th IACM Conference on Cannabinoids in Medicine will be held in Basel, Switzerland, from 14 to 16 October 2021.

Members only

Regular members can sign up for the new member area of the IACM to access exclusive content.

You need to become a regular member of the IACM to access the new member area.

IACM on Twitter

Follow us on twitter @IACM_Bulletin where you can send us inquiries and receive updates on research studies and news articles.